DOI:10.1111/1440-1681.13443 - Corpus ID: 228087337
Chrysophanol increases osteoblast differentiation via AMPK/Smad1/5/9 phosphorylation in vitro and in vivo
@article{Lim2020ChrysophanolIO, title={Chrysophanol increases osteoblast differentiation via AMPK/Smad1/5/9 phosphorylation in vitro and in vivo}, author={Young-Ju Lim and Kyeong-Min Kim and Won-Gu Jang}, journal={Clinical and Experimental Pharmacology and Physiology}, year={2020}, volume={48}, pages={515 - 523}, url={https://api.semanticscholar.org/CorpusID:228087337}}- Young-Ju LimKyeong-Min KimW. Jang
- Published inClinical and Experimental…9 December 2020
- Medicine
It is demonstrated that CA promotes osteoblast differentiation via AMPK/Smad1/5/9 expression in vitro and in vivo and used a zebrafish model to investigate the effect of CA on bone development to suggest that CA stimulated bone development via AM PK/SmAD1/ 5/9.
9 Citations
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The glycosyl groups increased the H-bond affinity between flavonoids and target sites, which weakened bone formation and predicted and verified the effect of icaritin, icariin, and baohuside-I in reversing glucocorticoid-induced bone formation inhibition by molecular docking and zebrafish model.
lncRNA ZNF710-AS1 Acts as a ceRNA for miR-146a-5p and miR-146b-5p to Accelerate Osteogenic Differentiation of PDLSCs by Upregulating the BMP6/Smad1/5/9 Pathway
Overexpression of ZNF710-AS1 significantly increased the osteogenic differentiation ability of PDLSCs by upregulating the expression of BMP6 and phosphorylation-SMAD family member 1/5/9 and competitively sponging miR- 146a-5p/miR-146b-5P and acting as a competing endogenous RNA (ceRNA).
The oxidative stress, mitochondrial pathway apoptosis, and the antagonistic effects of chrysophanol in SH-SY5Y cells via DTPP-induced photodynamic therapy.
- Liqing ZhengZehao LiZhaoxin WangLixia ShenJianhua Liu
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Chrysophanol exerts a protective effect against sepsis-induced acute myocardial injury through modulating the microRNA-27b-3p/Peroxisomal proliferating-activated receptor gamma axis
- Haiyan ZhaoYuping WangXiaolin Zhu
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Medicine, Environmental Science
It is revealed that Chrysophanol guarded against sepsis-mediated acute myocardial injury through dampening inflammation and apoptosis via the miR-27b-3p-PPARG axis, adding to the references for treating sepsi-AMI.
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Chrysophanol Induces Apoptosis of Choriocarcinoma Through Regulation of ROS and the AKT and ERK1/2 Pathways
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Biology, Medicine
Results indicate that chrysophanol is a potential effective chometherapeutic agent for treatment of choriocarcinoma therapy, and minimizing side effects of conventional treatment regimens.
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Medicine, Biology
Results indicate that the enhancement of osteoblast functionality by CIE may prevent osteoporosis and inflammatory bone diseases.
Anti-Inflammatory Activity of Chrysophanol through the Suppression of NF-κB/Caspase-1 Activation in Vitro and in Vivo
It is demonstrated that chrysophanol effectively attenuated overall clinical scores as well as various pathological markers of colitis and inhibited the production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and the expression of cyclooxygenase (COX)-2 levels induced by LPS.
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