The operation of pattern separation and pattern completion processes associated with different attributes or domains of memory

@article{Hunsaker2013TheOO,  title={The operation of pattern separation and pattern completion processes associated with different attributes or domains of memory},  author={Michael R. Hunsaker and Raymond P. Kesner},  journal={Neuroscience \& Biobehavioral Reviews},  year={2013},  volume={37},  pages={36-58},  url={https://api.semanticscholar.org/CorpusID:22493885}}

262 Citations

Pattern separation and pattern completion: Behaviorally separable processes?

Although overall accuracies for the two tasks correlated as expected, specific measures of individual variation in holistic retrieval and mnemonic discrimination did not correlate, suggesting that these two processes involve distinguishable properties of episodic memory.

An event-related potential investigation of pattern separation and pattern completion processes

ERP analysis is used to examine neuronal activity during performance of a mnemonic discrimination task and hypothesized that pattern separation processes would be reflected in correct rejection of similar lures while pattern completion processes would are reflected in falsely categorizing lures as repeated.

Tests of pattern separation and pattern completion in humans—A systematic review

Evidence is found that some of the parameters for task validity have been followed in some human studies of pattern separation and pattern completion, but no study was judged to have adequately met all the parametersFor task validity.

Extra-hippocampal contributions to pattern separation

The ‘cortico-hippocampal pattern separation’ (CHiPS) framework is proposed, which asserts that brain regions involved in cognitive control play a significant role in pattern separation by resolving interference in sensory regions that project to the hippocampus, thus regulating its cortical input.

A touchscreen-based paradigm to measure visual pattern separation and pattern completion in mice

A convenient, effective paradigm to evaluate pattern separation and pattern completion based on a touchscreen pairwise discrimination task is designed, which may provide a new method for the studies of the effects and mechanisms of memory accuracy enhancing drugs.

Pattern separation in the hippocampus through the eyes of computational modeling

A unifying framework is proposed whereby different network, cellular and sub‐cellular mechanisms converge to a common goal: controlling sparsity, the key determinant of pattern separation in the DG.

Pattern Separation: A Key Processing Deficit Associated with Aging?

This chapter reviews studies that have examined age-related changes in pattern separation in humans and rodents and discusses the potential basic science, translational, and clinical implications from these studies to illustrate the need to further examine the relationship between the brain changes associated with aging and pattern separation.

Memory Image Completion: Establishing a task to behaviorally assess pattern completion in humans

Evidence is presented that the MIC is a reliable behavioral task that targets pattern completion, that is easily and repeatedly applicable, and that is made freely available online.
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217 References

Overcoming interference: an fMRI investigation of pattern separation in the medial temporal lobe.

High-resolution fMRI data support the computational models' assertion that the hippocampus plays a key role in pattern separation, as activity within the hippocampus distinguished between correctly identified true stimulus repetitions, correctly rejected presentations of similar lure stimuli, and false alarms to similar lures.

Less efficient pattern separation may contribute to age-related spatial memory deficits

The present paper will review recently published studies in humans, non-human primates, and rodents that have examined age-related changes in spatial pattern separation to illustrate the need for future research to further examine the relationship betweenatial pattern separation and brain changes associated with aging and neurodegenerative disease.

Hippocampal conjunctive encoding, storage, and recall: Avoiding a trade‐off

This analysis is focused on the feedforward pathways from the entorhinal cortex to the dentate gyrus (DG) and region CA3 and finds that Hebbian synaptic modification facilitates completion but reduces separation, unless the strengths of synapses from inactive presynaptic units to active postsynaptic units are reduced (LTD).

A Behavioral Assessment of Hippocampal Function Based on a Subregional Analysis

Whether specific subregions (dentate gyrus, CA3, and CA1) of the hippocampus provide unique contributions to specific processes associated with intrinsic information processing exemplified by novelty detection, encoding, pattern separation, pattern association, pattern completion, retrieval, short-term memory and intermediate- term memory is determined.

Pattern Separation in the Human Hippocampal CA3 and Dentate Gyrus

High-resolution functional magnetic resonance imaging is used to measure brain activity during incidental memory encoding and provides compelling evidence of a key role of the human CA3/dentate gyrus in pattern separation.

Pattern separation in the dentate gyrus: A role for the CA3 backprojection

A simple CA3 network model is considered, and it is hypothesize that CA3 backprojections might play an important role in hippocampal function, and shows that the DG‐CA3 model with backprojection provides a better fit to empirical data than a model without back projections.

Further evidence in support of the neurobiological bases of an attribute model of memory: role of the hippocampus.

It can be concluded that there is good support for hippocampal involvement in a working or data-based memory system, but not a reference or expectancy- based memory system.
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