Synergistic effect of uncompetitive NMDA receptor antagonists and antidepressant drugs in the forced swimming test in rats

@article{Rog2002SynergisticEO,  title={Synergistic effect of uncompetitive NMDA receptor antagonists and antidepressant drugs in the forced swimming test in rats},  author={Zofia Rog{\'o}ż and Grażyna Skuza and Jerzy G. Maj and Wojciech Danysz},  journal={Neuropharmacology},  year={2002},  volume={42},  pages={1024-1030},  url={https://api.semanticscholar.org/CorpusID:20376278}}

187 Citations

Synergistic effect of imipramine and amantadine in the forced swimming test in rats. Behavioral and pharmacokinetic studies.

The above result suggests that the dopamine D(2/3) and alpha(1)-adrenergic receptors may contribute to the mechanism of synergistic action of IMI and AMA in the forced swimming test in rats.

The synergistic effect of selective sigma receptor agonists and uncompetitive NMDA receptor antagonists in the forced swim test in rats.

The obtained results give support to the hypothesis that sigma (particularly sigma1) receptors may be one of the possible mechanisms by which drugs induce antidepressant-like activity in the forced swim test, and that this effect may be enhanced by NMDA receptor antagonists.

Are NMDA Antagonists or Venlafaxine More Effective in the Forced Swimming Test?

The use of these combinations in the treatment of depression is important for the enhancement of antidepressant efficacy and the highest antidepressant-like effect was observed in the zinc-amantadine-amantadine-folic acid combination.

Involvement of NMDA receptors in the antidepressant-like action of adenosine

The results suggest that the effect ofadenosine in the FST is likely dependent on the inhibition of NMDA receptors mediated by the activation of adenosine A1 receptors.

Effect of NMDAR antagonists in the tetrabenazine test for antidepressants: comparison with the tail suspension test

Findings are consistent with the hypothesis that the inability of memantine, AZD6765 (lanicemine) and MK-0657 to reproduce the rapid and robust antidepressant effects of ketamine in the clinic result from insufficient dosing rather than a difference in mechanism of action among these NMDAR antagonists.

Effects of amantadine and budipine on antidepressant drug‐evoked changes in extracellular 5‐HT in the frontal cortex of freely moving rats

Combined treatment with clinically tolerated NMDA antagonists such as amantadine could reduce the delay in therapeutic onset of antidepressants as well as possibly enhance their efficacy.
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36 References

Synergistic effect of pramipexole and sertraline in the forced swimming test.

The obtained results indicate that sertraline--like the previously tested citalopram and fluoxetine--shows a synergistic effect when given with pramipexole in the forced swimming test.

A potential antidepressant activity of SA4503, a selective sigma 1 receptor agonist.

The suggestion that SA4503 may have potential antidepressive properties is supported, as it shows a synergistic effect with imipramine and decreased the immobility time in the forced swimming test in rats.

Synergistic effect of amantadine and imipramine in the forced swimming test.

The obtained results indicate that joint administration of amantadine and imipramine induced antidepressant-like effect in the forced swimming test even at doses of both drugs which were ineffective when each of the drugs was used alone.

The effect of CGP 37849 and CGP 39551, competitive NMDA receptor antagonists, in the forced swimming test.

The results obtained indicate that CGP 37849 and CGP 39551 induce an antidepressant-like effect in the forced swimming test, probably via an indirect dopamine activation resulting from blockade of NMDA receptors.

Amino-alkyl-cyclohexanes as a novel class of uncompetitive NMDA receptor antagonists.

The present review describes the rational for developing amino-alkyl-cyclohexanes, as new uncompetitive NMDA receptor antagonists based on positive experience with memantine, which has been used clinically for many years for the treatment of neurodegenerative dementia.

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