Molecular neurobiology of addiction: what’s all the (Δ)FosB about?

@article{Ruffle2014MolecularNO,  title={Molecular neurobiology of addiction: what’s all the ($\Delta$)FosB about?},  author={James K. Ruffle},  journal={The American Journal of Drug and Alcohol Abuse},  year={2014},  volume={40},  pages={428 - 437},  url={https://api.semanticscholar.org/CorpusID:19157711}}
The proposed role of ΔFosB is described and discussed, as well as the implications of recent findings, as a biomarker for the evaluation of potential therapeutic interventions for addiction.

82 Citations

Differential Expression of FosB Proteins and Potential Target Genes in Select Brain Regions of Addiction and Depression Patients

The first evidence of FosB gene expression in human HPC and PFC in these psychiatric disorders is provided, and data suggest that reduced ΔFosB in HPC could potentially underlie cognitive deficits accompanying chronic cocaine abuse or depression.

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This study explains how ΔFosB functions at the molecular level, focusing on its connections with dopamine D1 receptors, the cAMP/PKA signaling pathway, and its regulatory effects on downstream targets such as DARPP-32 and GluA1 AMPA receptor subunits.

Region-specific changes in markers of neuroplasticity revealed in HIV-1 transgenic rats by low-dose methamphetamine

Results reveal a region-specific activation of ERK, and increases in ΔFosB and D1R expression induced by HIV-1 proteins and meth, which may contribute to the neuronal and behavioral pathology associated with meth/HIV comorbidity.

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It is reported that dopamine D1 receptor signaling synergizes with the activin/ALK4/Smad3 pathway to potentiate the generation of ΔFosB mRNA in medium spiny neurons of the nucleus accumbens (NAc) via activation of the RNA‐binding protein PCBP1, a regulator of mRNA splicing.

Dopamine and ALK4 signaling synergize to induce PCBP1-mediated alternative splicing of FosB and sustained behavioral sensitization to cocaine

It is reported that dopamine D1 receptor signaling synergizes with the activin/ALK4/Smad3 pathway to potentiate the generation of ΔFosB mRNA in medium spiny neurons of the nucleus-accumbens (NAc) through activation of the RNA binding protein PCBP1, a regulator of mRNA splicing.
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132 References

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