Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia

@article{Walsh2008RareSV,  title={Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia},  author={Tom Walsh and Jon M McClellan and Shane E. McCarthy and Anjen{\'e} M. Addington and Sarah B Pierce and Gregory M. Cooper and Alex S. Nord and Mary Kusenda and Dheeraj Malhotra and Abhishek Bhandari and Sunday M. Stray and Caitlin Rippey and Patricia Roccanova and Vladimir Makarov and B. Lakshmi and Robert L. Findling and Linmarie Sikich and Thomas Stromberg and Barry Merriman and Nitin Gogtay and Philip Butler and Kristen L. Eckstrand and Laila Noory and Peter A. Gochman and Robert Long and Zugen Chen and Sean Davis and Carl A. Baker and Evan E. Eichler and Paul S. Meltzer and Stanley F. Nelson and Andrew B. Singleton and Ming K. Lee and Judith L. Rapoport and Mary-Claire King and Jonathan Sebat},  journal={Science},  year={2008},  volume={320},  pages={539 - 543},  url={https://api.semanticscholar.org/CorpusID:14385126}}
The results suggest that multiple, individually rare mutations altering genes in neurodevelopmental pathways contribute to schizophrenia, and disrupted genes disproportionately from signaling networks controlling neurodevelopment, including neuregulin and glutamate pathways.

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