Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding

@article{Schotte1996RisperidoneCW,  title={Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding},  author={Alain Schotte and Paul F.M. Janssen and Walter Gommeren and Walter Luyten and Paul T. Van Gompel and Anne Simone Josephine Lesage and K. De Loore and Jos{\'e}e E. Leysen},  journal={Psychopharmacology},  year={1996},  volume={124},  pages={57-73},  url={https://api.semanticscholar.org/CorpusID:12028979}}
In vitro, all compounds, except the ‘typical’ antipsychotics haloperidol and fluspirilene, showed higher affinity for 5HT2A than for D2 receptors, while in vivo, ORG-5222, risperidone, pipamperone, 9-OH-risperid one, sertindole, olanzapine, zotepine and clozapine maintained a higher potency for occupying 5HT

880 Citations

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