Dofetilide: a new class III antiarrhythmic agent

@article{Roukoz2007DofetilideAN,  title={Dofetilide: a new class III antiarrhythmic agent},  author={Henri Roukoz and Walid I. Saliba},  journal={Expert Review of Cardiovascular Therapy},  year={2007},  volume={5},  pages={19 - 9},  url={https://api.semanticscholar.org/CorpusID:11255636}}
Oral dofetilide did not increase mortality in patients with a recent myocardial infarction or congestive heart failure, hence its importance as an alternative medication for the pharmacological conversion of atrial fibrillation and flutter, and maintenance of sinus rhythm after conversion in patients at high risk of sudden death.

70 Citations

Relationship among amiodarone, new class III antiarrhythmics, miscellaneous agents and acquired long QT syndrome.

The main new generation class III drugs are: dofetilide, dronedarone, azimilide, and ibutilide, which are the gold standard in the prevention of recurrence of atrial fibrillation and flutter.

Newer Antiarrhythmic Agents for Atrial Fibrillation: Shall we Eventually do away with Proarrhythmia?

Future antiarrhythmic agents will probably be atrial-selective blocking agents without affecting repolarization in the ventricular myocardium and thus avoid ventricular proarrhythmics with its attendant life-threatening consequences.

Antiarrhythmic Effects of Combining Dofetilide and Ranolazine in a Model of Acutely Induced Atrial Fibrillation in Horses

The combination of dofetilide and ranolazine showed increased antiarrhythmic effects on acutely induced AF in horses, affecting time to cardioversion, AF vulnerability, and AF duration.

Clinical efficacy of dofetilide for the treatment of atrial tachyarrhythmias in adults with congenital heart disease.

D should be considered a pharmacologic alternative when adult patients with CHD develop AT but needs close monitoring for potential ventricular pro-arrhythmia.

Current Drug Treatment Strategies for Atrial Fibrillation and TASK-1 Inhibition as an Emerging Novel Therapy Option

The DOxapram Conversion TO Sinus rhythm (DOCTOS)-Trial will reveal whether doxaprams, a potent TASK-1 inhibitor, can be used for acute cardioversion of persistent and paroxysmal AF in patients, potentially leading to a new treatment option for AF.

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Dofetilide is more effective in patients with persistent than in those with paroxysmal AF/AFL, and short-term response does not necessarily predict long-term efficacy.

Synergistic Anti-arrhythmic Effects in Human Atria with Combined Use of Sodium Blockers and Acacetin

This study demonstrates synergistic antiarrhythmic benefits of combined block of IKur and INa, as well as those of INa and combined multi K+-current block of acacetin, without significant alterations of ventricular repolarization and QT intervals.

Dofetilide-Induced Microvolt T-Wave Alternans

In healthy subjects, dofetilide increases occurrence and levels (6 times baseline value on average) of TWA in the hours following its administration, and inhealthy subjects, this phenomenon is associated to malignant ventricular arrhythmias.
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62 References

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The results imply that the suppression of the development and maintenance of reentrant arrhythmias may result from the lengthening effect of dofetilide on the refractoriness and the consequent elimination of the excitable gap at the critical part of theReentrant loop.

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The epidemiology, pathophysiology, diagnosis, evaluation, and treatment of atrial fibrillation (AF) and atrial flutter (AFl) are reviewed, and recent developments and controversies in the approach to…
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