Estimating Consumer Exposure to PFOS and PFOA

@article{Trudel2008EstimatingCE,  title={Estimating Consumer Exposure to PFOS and PFOA},  author={David Trudel and Leah S. Horowitz and Matthias Wormuth and Martin Scheringer and Ian T. Cousins and Konrad Hungerb{\"u}hler},  journal={Risk Analysis},  year={2008},  volume={28},  url={https://api.semanticscholar.org/CorpusID:10777081}}
It is found that North American and European consumers are likely to experience ubiquitous and long-term uptake doses of PFOS and PFOA in the range of 3 to 220 ng per kg body weight per day (ng/kg(bw)/day) and 1 to 130 ng/kg (bw/day) respectively.

474 Citations

A Review of the Pathways of Human Exposure to Poly- and Perfluoroalkyl Substances (PFASs) and Present Understanding of Health Effects

Understanding of sources and trends in human exposure to poly- and perfluoroalkyl substances (PFASs) and epidemiologic evidence for impacts on cancer, immune function, metabolic outcomes, and neurodevelopment are reviewed.

Risk to human health related to the presence of perfluorooctane sulfonic acid and perfluorooctanoic acid in food

For PFOS, the increase in serum total cholesterol in adults, and the decrease in antibody response at vaccination in children were identified as the critical effects and the CONTAM Panel established a tolerable weekly intake (TWI) of 13 ng/kg body weight (bw) per week for PFOS and 6 ng/ kg bw for PFOA.

An assessment of the exposure of Americans to perfluorooctane sulfonate: A comparison of estimated intake with values inferred from NHANES data

A model that assesses exposure to perfluorooctane sulfonate (PFOS) and its precursors from both an intake and a body burden perspective and combines the two with a simple pharmacokinetic (PK) model is demonstrated and lends validity to the proposed framework.

Assessing potential human health and ecological implications of PFAS from leave-in dental products

The findings showed that PFOS and/or PFBA present in night guards were unlikely to pose a health concern, and dental products examined were shown to constitute a negligible contribution to environmental PFAS.

Human dietary exposure to per- and poly-fluoroalkyl substances (PFASs)

Dietary intake has been suggested as a major pathway of human exposure to the two most widely studied substances among PFSAs and PFCAs, and application of toxicokinetic models indicates that present day serum concentrations of PFOS and PFOA can largely be explained by the estimated dietary exposures.
...

104 References

Exposure assessment and risk characterization for perfluorooctanoate in selected consumer articles.

Exposures to PFO during consumer use of the articles evaluated in this study are not expected to cause adverse human health effects in infants, children, adolescents, adult residents, or professionals nor result in quantifiable levels of PFO in human serum.

Human exposure to perfluorinated chemicals through the diet: intake of perfluorinated compounds in foods from the Catalan (Spain) market.

The current results do not justify dietary intake as the main route of exposure governing blood concentrations of other PFCs, and a correlation between dietary intake and blood levels of PFOS is suggested.

Occurrence of perfluorinated substances in an adult German population in southern Bavaria

The data suggest that the current exposure of the adult German population is lower than the Exposure of the US and Canadian population, and the sources of human exposure are currently not well understood.

Sources, fate and transport of perfluorocarboxylates.

Transport pathways for PFCAs in the environment were reviewed, and it was concluded that, in addition to atmospheric transport/degradation of precursors, atmospheric and ocean water transport of the PFCA themselves could significantly contribute to their long-range transport.

Survey on PFOS and other perfluorinated compounds in Dutch fish and shellfish

Perfluorinated compounds (PFCs) are used in a wide variety of applications as a surfactant because of their ‘wetting’ properties. Other applications include moisture, stain and fat repellency for…

Concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) in vacuum cleaner dust collected in Japanese homes.

It was ascertained that PFOS and PFOA were present in the dust in homes, and that the absorption of the dust could be one of the exposure pathways of the PFOS/PFOA to humans.

Health risks in infants associated with exposure to perfluorinated compounds in human breast milk from Zhoushan, China.

No statistically significant correlation was found between concentrations of either PFOS or PFOA and maternal age, weight, or infant weight, but rate of consumption of fish was found to be positively correlated with PFNA, PFDA, and PFUnDA concentrations.
...

Related Papers

Showing 1 through 3 of 0 Related Papers