Genomic instability — an evolving hallmark of cancer

@article{Negrini2010GenomicI,  title={Genomic instability — an evolving hallmark of cancer},  author={Simona Negrini and Vassilis G. Gorgoulis and Thanos D. Halazonetis},  journal={Nature Reviews Molecular Cell Biology},  year={2010},  volume={11},  pages={220-228},  url={https://api.semanticscholar.org/CorpusID:10217969}}
The mutation patterns of the tumour suppressor TP53, ataxia telangiectasia mutated (ATM) and cyclin-dependent kinase inhibitor 2A (CDKN2A; which encodes p16INK4A and p14ARF) support the oncogene-induced DNA replication stress model, which attributes genomic instability and TP53 and ATM mutations to oncogen- induced DNA damage.

2,192 Citations

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