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GO logoAmiGO 2

hydroxymethylglutaryl-CoA hydrolase activity

Term Information

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Accession
GO:0047994
Name
hydroxymethylglutaryl-CoA hydrolase activity
Ontology
molecular_function
Synonyms
(S)-3-hydroxy-3-methylglutaryl-CoA hydrolase activity, 3-hydroxy-3-methylglutaryl-CoA hydrolase activity, beta-hydroxy-beta-methylglutaryl coenzyme A deacylase activity, beta-hydroxy-beta-methylglutaryl coenzyme A hydrolase activity, hydroxymethylglutaryl coenzyme A deacylase activity, hydroxymethylglutaryl coenzyme A hydrolase activity
Alternate IDs
None
Definition
Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H+.Source:RHEA:16305,EC:3.1.2.5
Comment
None
History
See termhistory for GO:0047994 at QuickGO
Chem. react.
has participanthydron
has participantwater
has participantcoenzyme A(4-)
has participant(3S)-3-hydroxy-3-methylglutaryl-CoA(5-)
has participant3-hydroxy-3-methylglutarate(2-)
Subset
None
Related
Linkto allgenes and gene products annotated to hydroxymethylglutaryl-CoA hydrolase activity (excluding "regulates").
Linkto all direct and indirectannotationsto hydroxymethylglutaryl-CoA hydrolase activity (excluding "regulates").
Linkto all direct and indirectannotations download (limited to first 10,000)for hydroxymethylglutaryl-CoA hydrolase activity (excluding "regulates").
Include "regulates"
For more information, please see theontology relation documentation.

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Parents of hydroxymethylglutaryl-CoA hydrolase activity (GO:0047994)
subject[Reorder by subject]relation[Reorder by relation]object[Reorder by object]
hydroxymethylglutaryl-CoA hydrolase activity[is_a relation] is_a acyl-CoA hydrolase activity (GO:0016289)
hydroxymethylglutaryl-CoA hydrolase activity[RO:0000057 relation] RO:0000057 hydron (CHEBI:15378)
hydroxymethylglutaryl-CoA hydrolase activity[RO:0000057 relation] RO:0000057 water (CHEBI:15377)
hydroxymethylglutaryl-CoA hydrolase activity[RO:0000057 relation] RO:0000057 coenzyme A(4-) (CHEBI:57287)
hydroxymethylglutaryl-CoA hydrolase activity[RO:0000057 relation] RO:0000057 (3S)-3-hydroxy-3-methylglutaryl-CoA(5-) (CHEBI:43074)
hydroxymethylglutaryl-CoA hydrolase activity[RO:0000057 relation] RO:0000057 3-hydroxy-3-methylglutarate(2-) (CHEBI:17325)

This term has no children.

EC
3.1.2.5
KEGG_REACTION
R02083
MetaCyc
HYDROXYMETHYLGLUTARYL-COA-HYDROLASE-RXN
RHEA
16305


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