calcidiol 1-monooxygenase activity

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Accession: GO:0004498
Name: calcidiol 1-monooxygenase activity
Ontology: molecular_function
Synonyms: 25-hydroxy vitamin D3 1-alpha-hydroxylase activity, 25-hydroxycholecalciferol 1-hydroxylase activity, calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating), 1-hydroxylase-25-hydroxyvitamin D3 activity, 25-OHD-1 alpha-hydroxylase activity, 25-hydroxy D3-1alpha-hydroxylase activity, 25-hydroxycholecalciferol 1-monooxygenase activity, 25-hydroxycholecalciferol 1alpha-hydroxylase activity, 25-hydroxycholecalciferol-1-hydroxylase activity, 25-hydroxyvitamin D-1 alpha hydroxylase activity, 25-hydroxyvitamin D3 1alpha-hydroxylase activity, cytochrome P450 CYP27B
Alternate IDs: None
Definition: Catalysis of the reaction: calcidiol + H+ + NADPH + O2 = calcitriol + H2O + NADP+.Source:RHEA:20573,EC:1.14.15.18
Comment: None
History: See termhistory for GO:0004498 at QuickGO
Chem. react.: has participantcalcidiol; has participantdi-mu-sulfido-diiron(2+); has participantwater; has participantcalcitriol; has participanthydron; has participantdioxygen; has participantdi-mu-sulfido-diiron(1+)
Subset: None
Related: Linkto allgenes and gene products annotated to calcidiol 1-monooxygenase activity (excluding "regulates").; Linkto all direct and indirectannotationsto calcidiol 1-monooxygenase activity (excluding "regulates").; Linkto all direct and indirectannotations download (limited to first 10,000)for calcidiol 1-monooxygenase activity (excluding "regulates").

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GO:0008150 biological_process
GO:0009987 cellular process
GO:0008152 metabolic process
GO:0044238 primary metabolic process
GO:0044281 small molecule metabolic process
GO:0009058 biosynthetic process
GO:0006629 lipid metabolic process
GO:0003674 molecular_function
GO:0044283 small molecule biosynthetic process
GO:0006766 vitamin metabolic process
GO:0006066 alcohol metabolic process
GO:0003824 catalytic activity
GO:0006775 fat-soluble vitamin metabolic process
GO:0008610 lipid biosynthetic process
GO:0008202 steroid metabolic process
GO:0009110 vitamin biosynthetic process
GO:0046165 alcohol biosynthetic process
GO:0042362 fat-soluble vitamin biosynthetic process
GO:0016491 oxidoreductase activity
GO:0019751 polyol metabolic process
GO:1902652 secondary alcohol metabolic process
GO:0006694 steroid biosynthetic process
GO:0042359 vitamin D metabolic process
GO:0004497 monooxygenase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0046173 polyol biosynthetic process
GO:0042368 vitamin D biosynthetic process
GO:0070640 vitamin D3 metabolic process
GO:0036378 calcitriol biosynthetic process from calciol
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0004498 calcidiol 1-monooxygenase activity
GO:0010956 negative regulation of calcidiol 1-monooxygenase activity
GO:0060559 positive regulation of calcidiol 1-monooxygenase activity
GO:0060558 regulation of calcidiol 1-monooxygenase activity

Parents of calcidiol 1-monooxygenase activity (GO:0004498)

subject	relation	object
calcidiol 1-monooxygenase activity	RO:0000057	calcidiol (CHEBI:17933)
calcidiol 1-monooxygenase activity	BFO:0000050	calcitriol biosynthetic process from calciol (GO:0036378)
calcidiol 1-monooxygenase activity	RO:0000057	di-mu-sulfido-diiron(2+) (CHEBI:33737)
calcidiol 1-monooxygenase activity	RO:0000057	water (CHEBI:15377)
calcidiol 1-monooxygenase activity	RO:0000057	calcitriol (CHEBI:17823)
calcidiol 1-monooxygenase activity	RO:0000057	hydron (CHEBI:15378)
calcidiol 1-monooxygenase activity	is_a	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen (GO:0016709)
calcidiol 1-monooxygenase activity	RO:0000057	dioxygen (CHEBI:15379)
calcidiol 1-monooxygenase activity	RO:0000057	di-mu-sulfido-diiron(1+) (CHEBI:33738)

Children of calcidiol 1-monooxygenase activity (GO:0004498)

subject	relation	object
positive regulation of calcidiol 1-monooxygenase activity (GO:0060559)	RO:0002213	calcidiol 1-monooxygenase activity
regulation of calcidiol 1-monooxygenase activity (GO:0060558)	RO:0002211	calcidiol 1-monooxygenase activity
negative regulation of calcidiol 1-monooxygenase activity (GO:0010956)	RO:0002212	calcidiol 1-monooxygenase activity

EC: 1.14.15.18
KEGG_REACTION: R03610
MetaCyc: CALCIDIOL-1-MONOOXYGENASE-RXN
Reactome: R-HSA-209868; R-HSA-5602186
RHEA: 20573

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calcidiol 1-monooxygenase activity

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Parents of calcidiol 1-monooxygenase activity (GO:0004498)

Children of calcidiol 1-monooxygenase activity (GO:0004498)