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| Clinical data | |
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| Trade names | Heptin, Heptadrine, Tuamine |
| Other names | Tuamine; 2-Aminoheptane; 2-Heptanamine; 1-Methylhexylamine |
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| ECHA InfoCard | 100.004.233 |
| Chemical and physical data | |
| Formula | C7H17N |
| Molar mass | 115.220 g·mol−1 |
| 3D model (JSmol) | |
| Density | 0.766 g/mL g/cm3 |
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Tuaminoheptane (INNTooltip International Nonproprietary Name,BANTooltip British Approved Name; brand namesHeptin,Heptadrine,Tuamine; also known astuamine and2-aminoheptane) is asympathomimetic agent andvasoconstrictor which was formerly used as anasal decongestant.[2][3][4] It is still used in France as a nasal decongestant but its use is not recommended by the health authorities due to the lack of evidence of its effectiveness. It has also been used as astimulant.[5][6]
Tuaminoheptane has been found to act as areuptake inhibitor andreleasing agent ofnorepinephrine, which may underlie its decongestant and stimulant effects.[7][8][6] It is analkylamine.[6] Thechemical structure of the drug differs from that of othernorepinephrine releasing agents, such as thephenethylamines, which, in contrast to tuaminoheptane, have anaromatic ring in their structure.[8] Tuaminoheptane is also askin irritant and can causecontact dermatitis viainhibition ofvolume-regulated anion channels, which limits its usefulness as a decongestant.[9]
Tuaminoheptane is on the 2011 list of prohibited substances published by theWorld Anti-Doping Agency.[5]
