This is a timeline of the development of prophylactic humanvaccines. Early vaccines may be listed by the first year of development or testing, but later entries usually show the year the vaccine finished trials and became available on the market. Although vaccines exist for the diseases listed below, onlysmallpox has been eliminated worldwide. The other vaccine-preventable illnesses continue to cause millions of deaths each year.^[1] Currently,polio andmeasles are the targets of active worldwideeradication campaigns.

• 1796 –Edward Jenner develops and documents firstvaccine forsmallpox.^[2]

• 1884-1885 – Firstvaccine forcholera byJaime Ferran y Clua^[3][4]
• 1881 - Firstvaccine foranthrax byLouis Pasteur^[5]
• 1885 – Firstvaccine forrabies byLouis Pasteur andÉmile Roux^[6][7]
• 1890 – Firstvaccine fortetanus (serum antitoxin) byEmil von Behring^[8]
• 1896 – Firstvaccine fortyphoid fever byAlmroth Edward Wright,Richard Pfeiffer, andWilhelm Kolle^[9]
• 1897 – Firstvaccine forbubonic plague byWaldemar Haffkine

• 1921 – Firstvaccine fortuberculosis byAlbert Calmette^[10][11]
• 1923 – Firstvaccine fordiphtheria byGaston Ramon,Emil von Behring andKitasato Shibasaburō
• 1924 – Firstvaccine forscarlet fever byGeorge F. Dick andGladys Dick
• 1924 – First inactivevaccine fortetanus (tetanus toxoid, TT) byGaston Ramon, C. Zoeller and P. Descombey
• 1926 – Firstvaccine forpertussis (whooping cough) byLeila Denmark
• 1932 – Firstvaccine foryellow fever byMax Theiler andJean Laigret
• 1937 – Firstvaccine fortyphus byRudolf Weigl,Ludwik Fleck andHans Zinsser
• 1937 – Firstvaccine forinfluenza by Anatol Smorodintsev^[12]
• 1941 – Firstvaccine fortick-borne encephalitis
• 1952 – First intravenousvaccine forpolio
• 1954 – Firstvaccine forJapanese encephalitis
• 1957 – Firstvaccine foradenovirus-4 and 7
• 1962 – First oral vaccine forpolio
• 1963 – Firstvaccine formeasles
• 1967 – Firstvaccine formumps
• 1970 – Firstvaccine forrubella
• 1977 – Firstvaccine forpneumonia (Streptococcus pneumoniae)
• 1978 – Firstvaccine formeningitis (Neisseria meningitidis)
• 1980 –Smallpox declared eradicated worldwide due to vaccination efforts
• 1981 – Firstvaccine forhepatitis B (first vaccine to target a cause ofcancer)
• 1984 – Firstvaccine forchicken pox
• 1985 – Firstvaccine forHaemophilus influenzae type b (HiB)
• 1989 – First vaccine forQ fever^[13]
• 1990 – Firstvaccine forhantavirus hemorrhagic fever with renal syndrome
• 1991 – Firstvaccine forhepatitis A^[14]
• 1998 – First vaccine forLyme disease
• 1998 – Firstvaccine forrotavirus^[15]

• 2000 – Firstpneumococcal conjugate vaccine approved in the U.S. (PCV7 or Prevnar)^[16]
• 2003 – First nasalinfluenza vaccine approved in U.S. (FluMist)
• 2003 – First vaccine forArgentine hemorrhagic fever.^[17]
• 2006 – Firstvaccine forhuman papillomavirus (which is a cause ofcervical cancer)
• 2006 – Firstherpes zoster vaccine forshingles
• 2011 – Firstvaccine fornon-small-cell lung carcinoma (comprises 85% oflung cancer cases)
• 2012 – First vaccine forhepatitis E^[18]
• 2012 – First quadrivalent (4-strain)influenza vaccine
• 2013 – First vaccine forenterovirus 71, one cause ofhand, foot, and mouth disease^[19]
• 2015 – Firstvaccine formalaria^[20]
• 2015 – Firstvaccine fordengue fever^[21]
• 2019 – Firstvaccine forEbola approved^[22]
• 2020 – Firstvaccine forCOVID-19
• 2023 – Firstrespiratory syncytial virus vaccine
• 2023 - Firstvaccine forChikungunya

• Medicine timelines
• Vaccines

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• Short description matches Wikidata
• Use dmy dates from March 2020