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Tigestol

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Tigestol
Identifiers
  • (8R,9S,13S,14S,17R)-17-ethynyl-13-methyl-2,3,4,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol
CAS Number
PubChemCID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC20H28O
Molar mass284.443 g·mol−1
3D model (JSmol)
  • CC12CCC3C(C1CCC2(C#C)O)CCC4=C3CCCC4
  • InChI=InChI=1S/C20H28O/c1-3-20(21)13-11-18-17-9-8-14-6-4-5-7-15(14)16(17)10-12-19(18,20)2/h1,16-18,21H,4-13H2,2H3/t16-,17-,18+,19+,20+/m1/s1
  • Key:DHOKBGHAEUVRMO-SLHNCBLASA-N

Tigestol (INN,USAN), also known as17α-ethynylestr-5(10)-en-17β-ol,[1] is asteroidalprogestin of the19-nortestosterone group that was developed byOrganon in the 1960s but was never marketed.[2][3][4][5] It is anisomer of the related 19-nortestosterone derivative progestinslynestrenol andcingestol.[6]

References

[edit]
  1. ^List PH, Hörhammer L (12 March 2013).Chemikalien und Drogen Teil C: T–Z. Springer-Verlag. pp. 179–.ISBN 978-3-642-67085-5.
  2. ^Hill RA, Makin HL, Kirk DN, Murphy GM (23 May 1991).Dictionary of Steroids. CRC Press. pp. 424–.ISBN 978-0-412-27060-4.
  3. ^United States Adopted Names (USAN). United States Pharmacopeial Convention. 1969. p. 65,85.
  4. ^Lednicer D, Mitscher LA (13 May 1980).The Organic Chemistry of Drug Synthesis. John Wiley & Sons. pp. 145–.ISBN 978-0-471-04392-8.
  5. ^Lednicer D (1998).Strategies for Organic Drug Synthesis and Design. Wiley. p. 95.ISBN 978-0-471-19657-0.
  6. ^GB 841411, "New 19-Nor-Steroid Compounds and process for the preparation thereof", published 1960-07-13, assigned toOrganon Laboratories Ltd. 
PRTooltip Progesterone receptor
Agonists
Mixed
(SPRMsTooltip Selective progesterone receptor modulators)
Antagonists
mPRTooltip Membrane progesterone receptor
(PAQRTooltip Progestin and adipoQ receptor)
Agonists
Antagonists
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