Template talk:Cannabinoids
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Why do people continue to remove URB597 and URB754 from the cannabinoids template? They belong in the group as cannabinoid modulatory substances esp. if Win55,212-2 gets included.
I've organized this template into groups. If anyone disagrees with the change, please discuss here. --Ccroberts05:23, 5 May 2007 (UTC)[reply]
Seems to me that inhibitors (URB597, AM404, URB754) should not be listed as 'cannabinoids.' My impression is that a 'cannabinoid' is anything that binds to cannabinoid receptors ("cannabinoid" means "cannabis-like"). Despite the fact that they cause cannabinoid-receptor mediated effects, inhibitors of enzymes that metabolize endocannabinoids (FAAH, MGL, etc) are not cannabinoids any more than aspirin is a prostaglandin.Roadnottaken17:18, 8 August 2007 (UTC)[reply]
i hate to bring up the same point again but to my intuition, a 'cannabinoid' is anything that is cannabis-like and CB receptor antagonists are the opposite. antagonists (AM251, rimonabant, etc) are anti-cannabinergic so i don't really see why they should be included in the 'synthetic cannabinoids' category. they should probably be listed on the template somewhere but this categorization really doesn't seem kosher to me.Roadnottaken (talk)16:39, 27 November 2007 (UTC)[reply]
Note that at least two other compounds are reported as having been used in smoking blends but have not been listed here as their structure has not been definitively identified, these are a derivative of JWH-018 with a methoxy on the indole ring (as opposed to the naphthyl ring as in JWH-081 or JWH-164) and a derivative of JWH-073 with an extra methyl group at an unidentified position (most likely the 2-position of the indole ring or the 4-position of the naphthyl ring, but could possibly be elsewhere). These will be added when the exact structures are verified by a reliable source.Meodipt (talk)02:19, 9 September 2010 (UTC)[reply]
It appears as if these might be the same compound, but Annual Reports in Medicinal Chemistry, Volume 12 (1977), page 15 shows A-42574 as the 1,1-dimethylheptyl compound, while nabazenil seems to be the 1,2-dimethylheptyl...the original paper that should clear this up (The Pharmacologist 1976;18:136) unfortunately does not appear to be available online.Meodipt (talk)05:05, 4 March 2011 (UTC)[reply]
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Would love to add plenty of substances to the list, including synaptamide, linoleoylethanolamide, VDM13 (5-methoxy-N-arachidonoyl-tryptamine), honokiol, magnolol, 4O-methylhonokiol, 4O-methylmagnolol, tetrahydromagnolol, AM-404, and others...SandraIndole (talk)08:15, 12 December 2018 (UTC)[reply]
Not done: it's not clear what changes you want to be made. Please mention the specific changes in a "change X to Y" format and provide areliable source if appropriate. –Jonesey95 (talk)11:41, 12 December 2018 (UTC)[reply]@Meodipt:THCB is listed in the template, is listsΔ9-THCB as a synonym in the article. However, Δ9-Tetrahydrocannabibutol (listed under page 11 athttps://www.bioscience.co.uk/userfiles/pdf/Cayman_Currents_34_Phytocannabinoids_2020SEP.pdf) is also abbreviatedΔ9-THCB so I didn't list it in the template yet. In the template, can you please rename THCB, and list Δ9-Tetrahydrocannabibutol (including its abbreviation)? --Bawanio (talk)06:57, 25 September 2022 (UTC)[reply]
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add ADB-BUTINACA to indazole-3-carboxamides in the synthetic cannabinoid receptor agonists categoryMilosiiii69 (talk)20:11, 22 November 2024 (UTC)[reply]
