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Phenprobamate

From Wikipedia, the free encyclopedia
Muscle relaxant drug
Pharmaceutical compound
Phenprobamate
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Legal status
Legal status
Pharmacokinetic data
Eliminationhalf-life5–8 hours
Identifiers
  • 3-Phenylpropylcarbamate
CAS Number
PubChemCID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.010.552Edit this at Wikidata
Chemical and physical data
FormulaC10H13NO2
Molar mass179.219 g·mol−1
3D model (JSmol)
  • O=C(OCCCc1ccccc1)N
  • InChI=1S/C10H13NO2/c11-10(12)13-8-4-7-9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H2,11,12) checkY
  • Key:CAMYKONBWHRPDD-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Phenprobamate (Gamaquil, Isotonil, Actozine) is a centrally actingskeletalmuscle relaxant, with additionalsedative andanticonvulsant effects.[2][unreliable source?] Itsmechanism of action is probably similar tomeprobamate. Phenprobamate has been used in humans as ananxiolytic, and is still sometimes used ingeneral anesthesia and for treating muscle cramps and spasticity. Phenprobamate is still used and available OTC in some European countries, but it has generally been replaced by newer drugs. It has been sold labeled as a nootropic. Phenprobamate is metabolized by oxidative degradation of thecarbamate group and ortho-hydroxylation of the benzene ring, and is eliminated in urine by the kidneys.[citation needed]

Doses range from 400 to 800 mg, up to 3 times a day.[3]

References

[edit]
  1. ^Anvisa (2023-03-31)."RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese).Diário Oficial da União (published 2023-04-04).Archived from the original on 2023-08-03. Retrieved2023-08-16.
  2. ^Demir B, Demir Y, Aksoy I, Kilic OH, Gucyetmez V, Savas HA (June 2015). "Phenprobamate dependence: a case report".Addictive Behaviors.45:232–3.doi:10.1016/j.addbeh.2015.01.037.PMID 25727392.
  3. ^"(meprobamate) dosing, indications, interactions, adverse effects, and more".Medscape. WebMD LLC. Retrieved21 March 2024.

Further reading

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External links

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