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NNC 63-0532

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From Wikipedia, the free encyclopedia

Chemical compound

Pharmaceutical compound

NNC 63-0532
Clinical data

Other names	NNC 63-0532
Identifiers
IUPAC name methyl [8-(1-naphthylmethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl)acetate
CAS Number	250685-44-0^Y
PubChemCID	9803475
ChemSpider	7979235
UNII	73663SY1DT
CompTox Dashboard(EPA)	DTXSID40397885
Chemical and physical data
Formula	C₂₇H₂₉N₃O₃
Molar mass	443.547 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES c3ccccc3N(CN(C2=O)CC(=O)OC)C2(CC4)CCN4Cc5c1ccccc1ccc5
InChI InChI=1S/C27H29N3O3/c1-33-25(31)19-29-20-30(23-11-3-2-4-12-23)27(26(29)32)14-16-28(17-15-27)18-22-10-7-9-21-8-5-6-13-24(21)22/h2-13H,14-20H2,1H3 Key:AQMPIDSGLFVVPL-UHFFFAOYSA-N
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NNC 63-0532 is anociceptoid drug used inscientific research. It acts as a potent and selectiveagonist for thenociceptin receptor, also known as the ORL-1 (opiate receptor-like 1) receptor.^[1]^[2]

The function of this receptor is not well understood, but it is believed to play a role in disorders likepain,drug addiction,opioid tolerance development, andpsychological disorders such asanxiety anddepression. Research into the function of this receptor is an important focus of currentpharmaceutical development, and selective agents such as NNC 63-0532 are essential for this work.^[3]