 | |
| Names | |
|---|---|
| IUPAC name N,N-dimethyl-5-[(4-biphenyl)methyl]tetrazole-1-carboxamide | |
| Identifiers | |
3D model (JSmol) | |
| ChEBI | |
| ChemSpider | |
| ECHA InfoCard | 100.189.657 |
| UNII | |
| |
| |
| Properties | |
| C17H17N5O | |
| Molar mass | 307.349 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
LY-2183240 is a drug which acts both as a potent inhibitor of thereuptake of theendocannabinoidanandamide and as an inhibitor offatty acid amide hydrolase (FAAH), the primaryenzyme responsible for degrading anandamide. This leads to markedly elevated anandamide levels in the brain, and LY-2183240 has been shown to produce bothanalgesic andanxiolytic effects in animal models.[1][2][3] While LY-2183240 is a potent inhibitor of FAAH, it has relatively poor selectivity and also inhibits several other enzyme side targets.[4] Consequently, it was never developed for clinical use, though it remains widely used in research, and has also been sold as adesigner drug.[5]
{{cite journal}}: CS1 maint: multiple names: authors list (link){{cite journal}}: CS1 maint: multiple names: authors list (link){{cite journal}}: CS1 maint: multiple names: authors list (link){{cite journal}}: CS1 maint: multiple names: authors list (link)Moore, S. A.; Nomikos, G. G.; Dickason-Chesterfield, A. K.; Schober, D. A.; Schaus, J. M.; Ying, B. P.; Xu, Y. C.; Phebus, L; Simmons, R. M.; Li, D; Iyengar, S; Felder, C. C. (2005)."Identification of a high-affinity binding site involved in the transport of endocannabinoids".Proceedings of the National Academy of Sciences.102 (49):17852–7.doi:10.1073/pnas.0507470102.PMC 1295594.PMID 16314570.
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