 | |
| Names | |
|---|---|
| IUPAC name Isopropyl dodecylphosphonofluoridate | |
| Preferred IUPAC name Propan-2-yl dodecylphosphonofluoridate | |
| Identifiers | |
3D model (JSmol) | |
| ChemSpider | |
| |
| |
| Properties | |
| C15H32FO2P | |
| Molar mass | 294.391 g·mol−1 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
IDFP is anorganophosphorus compound related to thenerve agentsarin.
Like sarin, IDFP is an irreversibleinhibitor for a number of different enzymes that normally serve to break down neurotransmitters, however the longalkyl chain of IDFP makes it dramatically weaker as an inhibitor ofacetylcholinesterase (AChE), with an IC50 of only 6300 nM, while it is a potent inhibitor of two enzymesmonoacylglycerol lipase (MAGL), the primaryenzyme responsible for degrading theendocannabinoid2-arachidonoylglycerol (2-AG), andfatty acid amide hydrolase (FAAH), the primary enzyme that degrades the other main endocannabinoidanandamide. The IC50 of IDFP is 0.8 nM at MAGL, and 3.0 nM at FAAH. Inhibition of these two enzymes causes markedly increased levels of both anandamide and 2-AG in the brain, resulting in increased cannabinoid signalling and typical cannabinoid behavioral effects in animal studies, while its lack of potency at AChE means that no cholinergic symptoms are produced.[1][2][3][4]
Despite its similar chemical structure to the banned nerve agents, the long alkyl chain of IDFP causes it to fall outside the definition of "toxic chemicals" under theChemical Weapons Convention,[5] and since it also does not exhibit the potent AChE inhibition of related organophosphorus compounds, IDFP is not subject to the same stringent legal controls.
