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| ECHA InfoCard | 100.019.512 |
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| Formula | C20H24N2O2S |
| Molar mass | 356.48 g·mol−1 |
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Hycanthone is theschistosomicide approved by the FDA in 1975. It is a metabolite oflucanthone. Hycanthone interferes withparasite nerve function, resulting inparalysis and death. This agent also intercalates into DNA and inhibits RNA synthesisin vitro and shows potentialantineoplastic activity.[1]
Hycanthone is shown to be an effective inhibitor ofacetylcholinesterase (AChE) fromSchistosoma mansoni, but is less potential against AChE from mammalian origin. This might come from differences in the configuration of active center between schistosome and mammalian AChE enzymes.[2]
Hycanthone is shown tointercalate into DNA and inhibit RNA synthesisin vitro. A growing body of evidence has shown that hycathone has anantineoplastic activity.[citation needed]
Hycanthone is a dose-dependenthepatotoxin,[3] causing hepatocellular injury.[4]
| Physical state | Solid |
| Solubility | Soluble in ethanol, methanol, DMSO, and water |
| Absorption maximum | 233, 258, 329, 438 nm |
| Melting point | 173-176 °C |
| logP | 3.74 |