Movatterモバイル変換

[0]ホーム

Jump to content

HCN3

Українська

Edit links

From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

HCN3

Identifiers

Aliases

HCN3, hyperpolarization activated cyclic nucleotide gated potassium channel 3

External IDs

OMIM:609973;MGI:1298211;HomoloGene:22453;GeneCards:HCN3;OMA:HCN3 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1q22	Start	155,277,463bp^[1]
Band	1q22	End	155,289,848bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	3\|3 F1	Start	89,053,381bp^[2]
Band	3\|3 F1	End	89,067,503bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right hemisphere of cerebellum

testicle

ganglionic eminence

mucosa of transverse colon

ventricular zone

pituitary gland

anterior pituitary

Hypothalamus

superior frontal gyrus

right frontal lobe

Top expressed in

neural layer of retina

perirhinal cortex

entorhinal cortex

pineal gland

barrel cortex

CA3 field

spinal ganglia

glossopharyngeal ganglion

olfactory bulb

choroid plexus of fourth ventricle

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	nucleotide binding potassium channel activity cAMP binding sodium channel activity voltage-gated ion channel activity ion channel activity voltage-gated potassium channel activity voltage-gated sodium channel activity protein binding
Cellular component	integral component of membrane membrane plasma membrane synapse soma axon dendrite cone cell pedicle integral component of plasma membrane
Biological process	sodium ion transmembrane transport sodium ion transport cellular response to dopamine regulation of membrane potential regulation of ion transmembrane transport ion transport potassium ion transport response to cisplatin transmembrane transport potassium ion transmembrane transport cellular response to cAMP
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


57657


15168

Ensembl


ENSG00000143630 ENSG00000263324


ENSMUSG00000028051

UniProt


Q9P1Z3


O88705

RefSeq (mRNA)


NM_020897


NM_008227

RefSeq (protein)


NP_065948


NP_032253

Location (UCSC)

Chr 1: 155.28 – 155.29 Mb

Chr 3: 89.05 – 89.07 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 is aprotein that in humans is encoded by theHCN3gene.^[5]^[6]

References

[edit]

^^a ^b ^cENSG00000263324 GRCh38: Ensembl release 89: ENSG00000143630, ENSG00000263324 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000028051 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Hofmann F, Biel M, Kaupp UB (Dec 2005). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels".Pharmacol Rev.57 (4):455–62.doi:10.1124/pr.57.4.8.PMID 16382102.S2CID 45853869.
^"Entrez Gene: HCN3 hyperpolarization activated cyclic nucleotide-gated potassium channel 3".

External links

[edit]

HCN3+protein,+human at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

Membrane transport protein:ion channels (TC 1A)

Ca²⁺:Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺:Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺:Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻:Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺:Proton channel	HVCN1
M⁺:CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺:TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+solutes):Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm:Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin