Gliding motility is a type of translocation used bymicroorganisms that is independent of propulsive structures such asflagella,pili, andfimbriae.[1] Gliding allows microorganisms to travel along the surface of low aqueous films. The mechanisms of this motility are only partially known.
Twitching motility also allows microorganisms to travel along a surface, but this type of movement is jerky and usespili as its means of transport. Bacterial gliding is a type of gliding motility that can also use pili for propulsion.
The speed of gliding varies between organisms, and the reversal of direction is seemingly regulated by some sort of internal clock.[2] For example theapicomplexans are able to travel at fast rates between 1–10 μm/s. In contrastMyxococcus xanthus bacteria glide at a rate of 0.08 μm/s.[3][4]
Bacterial gliding is a process of motility whereby abacterium can move under its own power. Generally, the process occurs whereby the bacterium moves along a surface in the general direction of its long axis.[5] Gliding may occur via distinctly different mechanisms, depending on the type of bacterium. This type of movement has been observed in phylogenetically diverse bacteria[6] such ascyanobacteria,myxobacteria,cytophaga,flavobacteria, andmycoplasma.
Bacteria move in response to varying climates, water content, presence of other organisms, and firmness of surfaces or media. Gliding has been observed in a wide variety of phyla, and though the mechanisms may vary between bacteria, it is currently understood that it takes place in environments with common characteristics, such as firmness and low-water, which enables the bacterium to still have motility in its surroundings. Such environments with low-water content includebiofilms,soil orsoil crumbs intilth, andmicrobial mats.[5]
a)Type IV pili: A cell attaches its pili to a surface or object in the direction it is traveling. The proteins in the pili are then broken down to shrink the pili pulling the cell closer to the surface or object that was it was attached to.[7]
b)Specific motility membrane proteins: Transmembrane proteins are attached to the host surface. This adhesion complex can either be specific to a certain type of surface like a certain cell type or generic for any solid surface. Motor proteins attached to an inner membrane force the movement of the internal cell structures in relation to the transmembrane proteins creating net movement.[8] This is driven by the proton motive force.[9] The proteins involved differ between species. An example of a bacterium that uses this mechanism would beFlavobacterium. This mechanism is still being studied and is not well understood.[10]
c)Polysaccharide jet: The cell releases a 'jet' of polysaccharide material behind it propelling it forward. This polysaccharide material is left behind.[11]Cell-invasion and gliding motility have TRAP (thrombospondin-related anonymous protein), a surface protein, as a common molecular basis that is both essential for infection and locomotion of the invasive apicomplexan parasite.[12]Micronemes are secretory organelles on the apical surface of the apicomplexans used for gliding motility.
Gliding, as a form of motility, appears to allow for interactions between bacteria,pathogenesis, and increased social behaviours. It may play an important role inbiofilm formation, bacterialvirulence, andchemosensing.[13]
Swarming motility occurs on softer semi-solid and solid surfaces (which usually involves movement of a bacterial population in a coordinated fashion viaquorum sensing, using flagella to propel them), ortwitching motility[6] on solid surfaces (which involves extension and retraction oftype IV pili to drag the bacterium forward).[14]
The mechanism of gliding might differ between species. Examples of such mechanisms include:
Motor proteins found within the inner membrane of the bacteria utilize a proton-conducting channel to transduce a mechanical force to the cell surface.[1] The movement of thecytoskeletalmicrofilaments causes a mechanical force which travels to the adhesion complexes on the substrate to move the cell forward.[15] Motor and regulatory proteins that convert intracellular motion into mechanical forces like traction force have been discovered to be a conserved class of intracellular motors in bacteria that have been adapted to produce cell motility.[15]
Ejection or secretion of apolysaccharide slime from nozzles at either end of the cell body.[18]
Energized nano-machinery or large macromolecular assemblies located on the bacterium's cell body.[15]
"Focal adhesion complexes" and "treadmilling" of surface adhesins distributed along the cell body.[13][2]
The gliding motility ofFlavobacterium johnsoniae uses a helical track superficially similar toM. xanthus, but via a different mechanism. Here the adhesin SprB is propelled along the cell surface (spiraling from pole to pole), pulling the bacterium along 25 times faster thanM. xanthus.[19]Flavobacterium johnsoniae move via a screw-like mechanism and are powered by a proton motive force.[20]
^abcMcBride, M. (2001). "Bacterial gliding motility: Multiple mechanisms for cell movement over surfaces".Annual Review of Microbiology.55:49–75.doi:10.1146/annurev.micro.55.1.49.PMID11544349.
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