Protein-coding gene in the species Homo sapiens
Protease-activated receptor 4 (PAR-4 ), also known ascoagulation factor II (thrombin) receptor-like 3 , is aprotein that in humans is encoded by theF2RL3 gene .[ 5]
Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of theprotease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellularamino terminus . The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated bythrombin andtrypsin .[ 5]
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