Earl Stadtman | |
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_(cropped).jpg) Earl Reece and Thressa Stadtman, 2004 | |
| Born | Earl Reece Stadtman (1919-11-15)November 15, 1919 Carrizozo,New Mexico, USA |
| Died | January 7, 2008(2008-01-07) (aged 88) Derwood, Maryland, USA[1] |
| Education | University of California, Berkeley (Ph.D. 1949) |
| Known for | Fatty aid biosynthesis, glutamine dehydrogenase, cycles of interconvertible enzymes |
| Spouse | Thressa Campbell Stadtman |
| Children | None |
| Awards | Pfizer Award in Enzyme Chemistry,American Academy of Arts and Sciences,National Academy of Sciences,National Medal of Science, many others |
| Scientific career | |
| Fields | Biochemistry |
| Institutions | Georgetown University, Washington, DC;University of Maryland,College Park, Maryland;Johns Hopkins University;National Heart Institute,Bethesda, Maryland; many visiting appointments |
| Thesis | Mechanisms of Fatty Acid Synthesis byClostridium kluyveri |
| Academic advisors | Horace Barker |
Earl Reece StadtmanNAS (November 15, 1919 – January 7, 2008)[2] was an Americanbiochemist,[1][3]notable for his research onenzymes[4]andanaerobic bacteria.
Stadtman started his career as a research assistant in the Division of Plant Nutrition of the University of California. Subsequently he was an Atomic Energy Commission Fellow with Fritz Lipmann in the Massachusetts General Hospital, but after 1960 he worked at theNational Heart Institute,where he became chief of the Laboratory of Biochemistry. In addition, he spent sabbatical periods at theMax Planck Institute in Munich and thePasteur Institute in Paris.[3]
In 1944 Earl Stadtman marriedThressa Campbell, also a distinguished scientist, the discoverer ofselenocysteine. They had no children during their marriage of more than sixty years.[5]
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Stadtman's research covered a wide field. Early in his career he worked withHorace Barker on bacterial fatty-acid synthesis, with a series of four papers.[6] In the same period he collaborated withFritz Lipmann on the function of coenzyme A.[7] Later his work took on a more enzymological character, with investigation of, for example, aldehyde dehydrogenase,[8] aspartate kinase,[9] work carried out during a period in the laboratory of Georges Cohen in France and, most notably, glutamine synthetase,[10] an enzyme that will always be associated with his name.
From the 1970s onwards Stadtman published many papers with P. Boon Chock on the capacity of cycles of interconvertible enzymes, based especially on his results with glutamine synthetase, to generate very high sensitivity to effectors.[11]
Stadtman was active as an editor of numerous prominent journals, including theJournal of Biological Chemistry, 1960–1965,Archives of Biochemistry and Biophysics, 1960–1969;Annual Review of Biochemistry, 1972–2000;Biochemistry, 1969–1976;Proceedings of the National Academy of Sciences, 1974–1981;Trends in Biochemical Sciences, 1975–1978.
He was (withBernard Horecker) founding editor ofCurrent Topics in Cellular Regulation, a major series in the subject, and continued in the role up to volume 23 (1984).
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