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EPH receptor A1

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

EPHA1

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
2K1K,2K1L,3HIL,3KKA

Identifiers

Aliases

EPHA1, Epha1, 5730453L17Rik, AL033318, Eph, Esk, EPHT, EPHT1, EPH receptor A1, EPH

External IDs

OMIM:179610;MGI:107381;HomoloGene:3835;GeneCards:EPHA1;OMA:EPHA1 - orthologs

Gene location (Human)

Chr.	Chromosome 7 (human)^[1]

Band	7q34-q35	Start	143,390,289bp^[1]
Band	7q34-q35	End	143,408,856bp^[1]

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)^[2]

Band	6\|6 B2.1	Start	42,335,421bp^[2]
Band	6\|6 B2.1	End	42,350,202bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

skin of leg

skin of abdomen

right uterine tube

right lobe of liver

minor salivary glands

vagina

left lobe of thyroid gland

ectocervix

mucosa of transverse colon

right lung

Top expressed in

tail of embryo

esophagus

embryo

epiblast

female urethra

right kidney

ascending aorta

male urethra

genital tubercle

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	transferase activity protein kinase activity nucleotide binding transmembrane-ephrin receptor activity kinase activity transmembrane receptor protein tyrosine kinase activity protein tyrosine kinase activity ATP binding protein kinase binding ephrin receptor activity receptor tyrosine kinase transmembrane signaling receptor activity
Cellular component	integral component of membrane membrane plasma membrane integral component of plasma membrane cytoplasm neuron projection receptor complex
Biological process	somatic stem cell population maintenance negative regulation of protein kinase activity activation of GTPase activity phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cell-matrix adhesion positive regulation of cell migration regulation of GTPase activity positive regulation of angiogenesis protein phosphorylation cell surface receptor signaling pathway negative regulation of cell migration cell adhesion angiogenesis positive regulation of cell population proliferation protein autophosphorylation peptidyl-tyrosine phosphorylation substrate adhesion-dependent cell spreading positive regulation of stress fiber assembly ephrin receptor signaling pathway negative regulation of signal transduction cell differentiation negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade axon guidance
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


2041


13835

Ensembl


ENSG00000146904 ENSG00000284816


ENSMUSG00000029859

UniProt


P21709


Q60750

RefSeq (mRNA)


NM_005232


NM_023580

RefSeq (protein)


NP_005223


NP_076069

Location (UCSC)

Chr 7: 143.39 – 143.41 Mb

Chr 6: 42.34 – 42.35 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

EPH receptor A1 (ephrin type-A receptor 1) is aprotein that in humans is encoded by theEPHA1gene.^[5]^[6]

This gene belongs to theephrin receptor subfamily of theprotein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in thenervous system. Receptors in the EPH subfamily typically have a singlekinase domain and an extracellular region containing a Cys-rich domain and 2fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-Bligands. This gene is expressed in some humancancer cell lines and has been implicated incarcinogenesis.^[6]

References

[edit]

^^a ^b ^cENSG00000284816 GRCh38: Ensembl release 89: ENSG00000146904, ENSG00000284816 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000029859 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ephnomenclaturecommittee (Sep 1997)."Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee".Cell.90 (3):403–4.doi:10.1016/S0092-8674(00)80500-0.PMID 9267020.S2CID 26773768.
^^a ^b"Entrez Gene: EPHA1 EPH receptor A1".

Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development".Annu. Rev. Neurosci.21:309–45.doi:10.1146/annurev.neuro.21.1.309.PMID 9530499.
Zhou R (1998). "The Eph family receptors and ligands".Pharmacol. Ther.77 (3):151–81.doi:10.1016/S0163-7258(97)00112-5.PMID 9576626.
Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis".Development.126 (10):2033–44.doi:10.1242/dev.126.10.2033.PMID 10207129.
Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly".Int. Rev. Cytol. International Review of Cytology.196:177–244.doi:10.1016/S0074-7696(00)96005-4.ISBN 9780123646002.PMID 10730216.
Xu Q, Mellitzer G, Wilkinson DG (2001)."Roles of Eph receptors and ephrins in segmental patterning".Philos. Trans. R. Soc. Lond. B Biol. Sci.355 (1399):993–1002.doi:10.1098/rstb.2000.0635.PMC 1692797.PMID 11128993.
Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development".Nat. Rev. Neurosci.2 (3):155–64.doi:10.1038/35058515.PMID 11256076.S2CID 205014301.
Hirai H, Maru Y, Hagiwara K, et al. (1988). "A novel putative tyrosine kinase receptor encoded by the eph gene".Science.238 (4834):1717–20.doi:10.1126/science.2825356.PMID 2825356.
Gale NW, Holland SJ, Valenzuela DM, et al. (1996)."Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis".Neuron.17 (1):9–19.doi:10.1016/S0896-6273(00)80276-7.PMID 8755474.S2CID 1075856.
Owshalimpur D, Kelley MJ (1999)."Genomic structure of the EPHA1 receptor tyrosine kinase gene".Mol. Cell. Probes.13 (3):169–73.doi:10.1006/mcpr.1999.0228.PMID 10369740.
Kalo MS, Pasquale EB (October 1999). "Signal transfer by eph receptors".Cell and Tissue Research.298 (1):1–9.doi:10.1007/pl00008807.PMID 10502115.S2CID 1241074.
Coulthard MG, Lickliter JD, Subanesan N, et al. (2002). "Characterization of the Epha1 receptor tyrosine kinase: expression in epithelial tissues".Growth Factors.18 (4):303–17.doi:10.3109/08977190109029118.PMID 11519828.S2CID 43039239.
Hillier LW, Fulton RS, Fulton LA, et al. (2003)."The DNA sequence of human chromosome 7".Nature.424 (6945):157–64.Bibcode:2003Natur.424..157H.doi:10.1038/nature01782.PMID 12853948.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation".Nat. Biotechnol.22 (6):707–16.doi:10.1038/nbt971.PMID 15146197.S2CID 27764390.

v t e PDB gallery
1x5a: The solution structure of the second fibronectin type III domain of mouse Ephrin type-A receptor 1

Protein kinases:tyrosine kinases (EC 2.7.10)

Receptor tyrosine kinases (EC 2.7.10.1)

Growth factor receptors

EGF receptor family	EGFR ERBB2 ERBB3 ERBB4
Insulin receptor family	IGF1R INSR INSRR
PDGF receptor family	CSF1R FLT3 KIT PDGFR (PDGFRA PDGFRB)
FGF receptor family	FGFR1 FGFR2 FGFR3 FGFR4
VEGF receptors family	VEGFR1 VEGFR2 VEGFR3
HGF receptor family	MET RON
Trk receptor family	NTRK1 NTRK2 NTRK3

EPH receptor family

LTK receptor family

TIE receptor family

ROR receptor family

DDR receptor family

PTK7 receptor family

PTK7

RYK receptor family

MuSK receptor family

MUSK

ROS receptor family

ROS1

AATYK receptor family

AXL receptor family

RET receptor family

uncategorised

STYK1

Non-receptor tyrosine kinases (EC 2.7.10.2)

ABL family	ABL1 ARG
ACK family	ACK1 TNK1
CSK family	CSK MATK
FAK family	FAK PYK2
FES family	FES FER
FRK family	FRK BRK SRMS
JAK family	JAK1 JAK2 JAK3 TYK2
SRC-A family	SRC FGR FYN YES1
SRC-B family	BLK HCK LCK LYN
TEC family	TEC BMX BTK ITK TXK
SYK family	SYK ZAP70

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1Oxidoreductases (list) EC2Transferases (list) EC3Hydrolases (list) EC4Lyases (list) EC5Isomerases (list) EC6Ligases (list) EC7Translocases (list)

Growth factor receptor modulators

Angiopoietin

Agonists:Angiopoietin 1
Angiopoietin 4

Antagonists:Angiopoietin 2
Angiopoietin 3

Kinase inhibitors:Altiratinib
CE-245677
Rebastinib

Antibodies:Evinacumab (against angiopoietin 3)
Nesvacumab (against angiopoietin 2)

CNTF

EGF (ErbB)

EGF (ErbB1/HER1)	Agonists:Amphiregulin Betacellulin EGF (urogastrone) Epigen Epiregulin Heparin-binding EGF-like growth factor (HB-EGF) Murodermin Nepidermin Transforming growth factor alpha (TGFα) Kinase inhibitors:Afatinib Agerafenib Brigatinib Canertinib Dacomitinib Erlotinib Gefitinib Grandinin Icotinib Lapatinib Neratinib Osimertinib Vandetanib WHI-P 154 Antibodies:Cetuximab Depatuxizumab Depatuxizumab mafodotin Futuximab Imgatuzumab Matuzumab Necitumumab Nimotuzumab Panitumumab Zalutumumab
ErbB2/HER2	Agonists:Unknown/none Antibodies:Ertumaxomab Pertuzumab Trastuzumab Trastuzumab deruxtecan Trastuzumab duocarmazine Trastuzumab emtansine Kinase inhibitors:Afatinib Lapatinib Mubritinib Neratinib Tucatinib
ErbB3/HER3	Agonists:Neuregulins (heregulins) (1,2,6 (neuroglycan C)) Antibodies:Duligotumab Patritumab Seribantumab
ErbB4/HER4	Agonists:Betacellulin Epigen Heparin-binding EGF-like growth factor (HB-EGF) Neuregulins (heregulins) (1,2,3,4,5 (tomoregulin, TMEFF))

FGF

FGFR1	Agonists:Ersofermin FGF (1,2 (bFGF),3,4,5,6,8,10 (KGF2),20) Repifermin Selpercatinib Trafermin Velafermin
FGFR2	Agonists:Ersofermin FGF (1,2 (bFGF),3,4,5,6,7 (KGF),8,9,10 (KGF2),17,18,22) Palifermin Repifermin Selpercatinib Sprifermin Trafermin Antibodies:Aprutumab Aprutumab ixadotin Kinase inhibitors:Infigratinib
FGFR3	Agonists:Ersofermin FGF (1,2 (bFGF),4,8,9,18,23) Selpercatinib Sprifermin Trafermin Antibodies:Burosumab (against FGF23)
FGFR4	Agonists:Ersofermin FGF (1,2 (bFGF),4,6,8,9,19) Trafermin
Unsorted	Agonists:FGF15/19

HGF (c-Met)

Agonists:Fosgonimeton
Hepatocyte growth factor

Potentiators:Dihexa (PNB-0408)

IGF

IGF-1	Agonists:des(1-3)IGF-1 Insulin-like growth factor-1 (somatomedin C) IGF-1 LR3 Insulin-like growth factor-2 (somatomedin A) Insulin Mecasermin Mecasermin rinfabate Kinase inhibitors:BMS-754807 Linsitinib NVP-ADW742 NVP-AEW541 OSl-906 Antibodies:AVE-1642 Cixutumumab Dalotuzumab Figitumumab Ganitumab Robatumumab R1507 Teprotumumab Xentuzumab (against IGF-1 and IGF-2)
IGF-2	Agonists:Insulin-like growth factor-2 (somatomedin A) Antibodies:Dusigitumab Xentuzumab (against IGF-1 and IGF-2)
Others	Binding proteins:IGFBP (1,2,3,4,5,6,7) Cleavage products/derivatives with unknown target:Glypromate (GPE, (1-3)IGF-1) Trofinetide

LNGF (p75^NTR)

Antibodies:Against NGF:ABT-110 (PG110)
ASP-6294
Fasinumab
Frunevetmab
Fulranumab
MEDI-578
Ranevetmab
Tanezumab

Aptamers:Against NGF:RBM-004

Decoy receptors:LEVI-04 (p75^NTR-Fc)

PDGF

Agonists:Becaplermin
Platelet-derived growth factor (A,B,C,D)

RET (GFL)

GFRα1	Agonists:Glial cell line-derived neurotrophic factor (GDNF) Liatermin Kinase inhibitors:Vandetanib
GFRα2	Agonists:Neurturin (NRTN) Kinase inhibitors:Vandetanib
GFRα3	Agonists:Artemin (ARTN) Kinase inhibitors:Vandetanib
GFRα4	Agonists:Persephin (PSPN) Kinase inhibitors:Vandetanib
Unsorted	Kinase inhibitors:Agerafenib

SCF (c-Kit)

Agonists:Ancestim
Stem cell factor

TGFβ

Seehere instead.

Trk

TrkA	Agonists:Amitriptyline BNN-20 BNN-27 Cenegermin DHEA DHEA-S Gambogic amide NGF Tavilermide Antagonists:ALE-0540 Dexamethasone FX007 Testosterone Negative allosteric modulators:VM-902A Kinase inhibitors:Altiratinib AZD-6918 CE-245677 CH-7057288 DS-6051 Entrectinib GZ-389988 K252a Larotrectinib Lestaurtinib Milciclib ONO-4474 ONO-5390556 PLX-7486 Rebastinib SNA-120 (pegylated K252a)) Antibodies:Against TrkA:GBR-900;Against NGF:ABT-110 (PG110) ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers:Against NGF:RBM-004 Decoy receptors:ReN-1820 (TrkAd5)
TrkB	Agonists:3,7-DHF 3,7,8,2'-THF 4'-DMA-7,8-DHF 7,3'-DHF 7,8-DHF 7,8,2'-THF 7,8,3'-THF Amitriptyline BDNF BNN-20 Deoxygedunin Deprenyl Diosmetin DMAQ-B1 HIOC LM22A-4 N-Acetylserotonin NT-3 NT-4 Norwogonin (5,7,8-THF) R7 R13 TDP6 Antagonists:ANA-12 Cyclotraxin B Gossypetin (3,5,7,8,3',4'-HHF) Ligands:DHEA Kinase inhibitors:Altiratinib AZD-6918 CE-245677 CH-7057288 DS-6051 Entrectinib GZ-389988 K252a Larotrectinib Lestaurtinib ONO-4474 ONO-5390556 PLX-7486
TrkC	Agonists:BNN-20 DHEA NT-3 Kinase inhibitors:Altiratinib AZD-6918 CE-245677 CH-7057288 DS-6051 Entrectinib GZ-389988 K252a Larotrectinib Lestaurtinib ONO-4474 ONO-5390556 PLX-7486