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Decoglurant

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Chemical compound

Pharmaceutical compound

Decoglurant
Clinical data

ATC code	none
Legal status
Legal status	Development terminated
Identifiers
IUPAC name 5-({7-(Trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl}ethynyl)-2-pyridinamine
CAS Number	911115-16-7
PubChemCID	71533696
ChemSpider	32695160
UNII	5VX4P0JKC5
KEGG	D10875
CompTox Dashboard(EPA)	DTXSID001031872
Chemical and physical data
Formula	C₂₁H₁₁F₆N₅
Molar mass	447.344 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1=CC(=CC=C1C2=NC3=C(C=NN3C(=C2)C(F)(F)F)C#CC4=CN=C(C=C4)N)C(F)(F)F
InChI InChI=1S/C21H11F6N5/c22-20(23,24)15-6-4-13(5-7-15)16-9-17(21(25,26)27)32-19(31-16)14(11-30-32)3-1-12-2-8-18(28)29-10-12/h2,4-11H,(H2,28,29) Key:DMJHZVARRXJSEG-UHFFFAOYSA-N

Decoglurant (INN) (code nameRG1578,RO4995819) is anegative allosteric modulator of themGlu₂ andmGlu₃ receptors which was under development byRoche for theadjunctive treatment ofmajor depressive disorder.^[1]^[2] Decoglurant progressed as far asphase II clinical trials^[1]^[2] but was ultimately discontinued from further development due to disappointing efficacy results.^[3]^[4]

^^a ^b"Roche – Pipeline". 2014. Archived fromthe original on 2022-10-23. Retrieved2014-08-01.
^^a ^b"Roche Group Development Pipeline"(PDF). 2014. Archived fromthe original(PDF) on 2014-08-08. Retrieved2014-08-01.
^"Roche – Pipeline"(PDF). 2015. Archived fromthe original(PDF) on 2015-05-01. Retrieved2015-05-14.
^Lawrence J (March 2015)."The Secret Life of ketamine".The Pharmaceutical Journal.294 (7854/5).

mGluR₁Tooltip Metabotropic glutamate receptor 1	Agonists:ACPD DHPG Glutamate Ibotenic acid Quisqualic acid Ro01-6128 Ro67-4853 Ro67-7476 VU-71 Theanine Antagonists:BAY 36-7620 CPCCOEt Cyclothiazide LY-367,385 LY-456,236 MCPG NPS-2390
mGluR₅Tooltip Metabotropic glutamate receptor 5	Agonists:ACPD ADX-47273 CDPPB CHPG DFB DHPG Glutamate Ibotenic acid Quisqualic acid VU-1545;Positive allosteric modulators:LSN2463359 Antagonists:CTEP DMeOB LY-344,545 Mavoglurant MCPG NPS-2390 Remeglurant SIB-1757 SIB-1893;Negative allosteric modulators:AZD9272 Basimglurant Dipraglurant Fenobam GRN-529 MPEP MTEP Raseglurant

mGluR₂Tooltip Metabotropic glutamate receptor 2	Agonists:BINA CBiPES DCG-IV Eglumegad Glutamate Ibotenic acid LY-379,268 LY-404,039 (pomaglumetad) LY-487,379 LY-566,332 MGS-0028 Pomaglumetad methionil (LY-2140023) Talaglumetad;Positive allosteric modulators:JNJ-40411813 (ADX-71149) Antagonists:APICA CECXG EGLU HYDIA LY-307,452 LY-341,495 MCPG MGS-0039 PCCG-4;Negative allosteric modulators:Decoglurant RO4491533
mGluR₃Tooltip Metabotropic glutamate receptor 3	Agonists:CBiPES DCG-IV Eglumegad Glutamate Ibotenic acid LY-379,268 LY-404,039 (pomaglumetad) LY-487,379 MGS-0028 Pomaglumetad methionil (LY-2140023) Talaglumetad Antagonists:APICA CECXG EGLU HYDIA LY-307,452 LY-341,495 MCPG MGS-0039;Negative allosteric modulators:Decoglurant RO4491533

mGluR₄Tooltip Metabotropic glutamate receptor 4	Agonists:Glutamate L-AP4 LSP2-9166 PHCCC VU-001,171 VU-0155,041;Positive allosteric modulators:Foliglurax MPEP Antagonists:CPPG MAP4 MPPG MSOP MTPG UBP-1112
mGluR₆Tooltip Metabotropic glutamate receptor 6	Agonists:Glutamate L-AP4 Antagonists:CPPG MAP4 MPPG MSOP MTPG UBP-1112
mGluR₇Tooltip Metabotropic glutamate receptor 7	Agonists:AMN082 Glutamate L-AP4 LSP2-9166 Antagonists:CPPG MAP4 MMPIP MPPG MSOP MTPG UBP-1112 XAP044;Negative allosteric modulators:ADX71743
mGluR₈Tooltip Metabotropic glutamate receptor 8	Agonists:DCPG Glutamate L-AP4;Positive allosteric modulators:AZ12216052 Antagonists:CPPG MAP4 MPPG MSOP MTPG UBP-1112

See also:Receptor/signaling modulators •Ionotropic glutamate receptor modulators •Glutamate metabolism/transport modulators

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