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Coriamyrtin

From Wikipedia, the free encyclopedia
Convulsant toxin
Coriamyrtin[1]
Names
IUPAC name
(1S,2R,3S,5R,6R,7R,9S,12R)-2-Hydroxy-7-methyl-12-prop-1-en-2-ylspiro[4,10-dioxatetracyclo[7.2.1.02,7.03,5]dodecane-6,2'-oxirane]-11-one
Other names
Coriamyrtine
Identifiers
3D model (JSmol)
  • InChI=1S/C15H18O5/c1-6(2)8-7-4-13(3)14(5-18-14)10-11(20-10)15(13,17)9(8)12(16)19-7/h7-11,17H,1,4-5H2,2-3H3/t7-,8+,9+,10+,11-,13-,14+,15-/m0/s1
    Key: BWWDLKVKPVKBGJ-TWMZOSGRSA-N
  • CC(=C)C1C2CC3(C4(CO4)C5C(C3(C1C(=O)O2)O)O5)C
Properties
C15H18O5
Molar mass278.304 g·mol−1
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
Chemical compound

Coriamyrtin is a toxicγ-lactone naturally present in a multitude of plants.

Natural occurrence

[edit]

Coriamyrtin can be found inScurrula parasitica,[2]Coriaria microphylla,[3]Coriaria nepalensis,[4] and certain other plants.

Toxicity

[edit]

Coriamyrtin is aconvulsant.[5] It appears to act viaantagonism ofGABAA receptors.[6] Poisoning is usually from ingestion of parts of the plants containing it. A case of poisoning was able to be treated with repeated administration ofdiazepam, ananticonvulsant.[4]

References

[edit]
  1. ^"Coriamyrtin".
  2. ^PubChem."Scurrula parasitica".pubchem.ncbi.nlm.nih.gov. Retrieved2024-02-11.
  3. ^PubChem."Coriaria microphylla".pubchem.ncbi.nlm.nih.gov. Retrieved2024-02-11.
  4. ^abDe Haro, Luc; Pommier, Philip; Tichadou, Lucia; Hayek-Lanthois, Maryvonne; Arditti, Jocelyne (2005). "Poisoning by Coriaria myrtifolia Linnaeus: A new case report and review of the literature".Toxicon.46 (6):600–603.Bibcode:2005Txcn...46..600D.doi:10.1016/j.toxicon.2005.06.026.PMID 16165183.
  5. ^"T3DB: Coriamyrtin".www.t3db.ca. Retrieved2024-02-11.
  6. ^Pérez, Claudia; Becerra, José; Manríquez-Navarro, Paula; Aguayo, Luis Gerardo; Fuentealba, Jorge; Guzmán, José Leonardo; Joseph-Nathan, Pedro; Jiménez, Verónica; Muñoz, Marcelo Andrés; Silva, Mario (2011)."Inhibitory activities on mammalian central nervous system receptors and computational studies of three sesquiterpene lactones from Coriaria ruscifolia subsp. ruscifolia".Chemical & Pharmaceutical Bulletin.59 (2):161–165.doi:10.1248/cpb.59.161.ISSN 1347-5223.PMID 21297293.
Ionotropic
GABAATooltip γ-Aminobutyric acid A receptor
GABAATooltip γ-Aminobutyric acid A-rho receptor
Metabotropic
GABABTooltip γ-Aminobutyric acid B receptor
GABA receptor antagonists
GABA synthesis inhibitors
Glycine receptor antagonists
Glutamate receptor agonists
Convulsantbarbiturates
Other
Animal toxins
Bacterial
Cyanotoxins
Plant toxins
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Pesticides
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Bicyclic phosphates
Cholinergic neurotoxins
Psychoactive drugs
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