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 Aerial view of City of Hope campus in 2021 | |
| Formation | 1913 |
|---|---|
| Type | Nonprofit,charitable organization |
| Purpose | Clinical research, medical treatment,education |
| Headquarters | Duarte, California |
| Location | |
| Membership | National Cancer Institute-designated Comprehensive Cancer Center,National Comprehensive Cancer Network |
President and CEO | Robert W. Stone[1] |
Provost and chief scientific officer | Steven T. Rosen[2] |
| Affiliations | Association of Community Cancer Centers, National Bone Marrow Transplantation Research Network, National Gene Vector Laboratory, Southern California Islet Cell Consortium, Islet Cell Transplant Center,Juvenile Diabetes Research Foundation |
| Website | |
City of Hope is a private, non-profitclinical research center,hospital andgraduate school located inDuarte, California, United States. The center's main campus resides on 110 acres (45 ha) of land adjacent to the boundaries of Duarte andIrwindale, with a network of clinical practice locations throughout Southern California, satellite offices inMonrovia and Irwindale, and regional fundraising offices throughout the United States.[citation needed]
City of Hope is best known as acancer treatment center. It has been designated aComprehensive Cancer Center by theNational Cancer Institute. City of Hope has also been ranked one of the nation's Best Cancer Hospitals byU.S. News & World Report for over ten years and is a founding member of theNational Comprehensive Cancer Network.
City of Hope played a role in the development ofsynthetic human insulin in 1978. The center has performed 13,000hematopoietic stem cell transplants as of 2016 with patient outcomes that consistently exceed national averages.[citation needed]
In the late 19th and early 20th centuries, the spread oftuberculosis, also known as "consumption", was a growing concern in the United States and Europe. Owing to advancements in the scientific understanding of its contagious nature, amovement to house and quarantine sufferers became prevalent. Construction oftuberculosis sanatoria, including tent cities, became common in the United States, with many sanatoriums located in theSouthwestern United States, where it was believed that the more arid climate would aid sufferers.
In 1913, theJewish Consumptive Relief Association was chartered in Los Angeles, California, with the intent of raising money to establish a free, non-sectariansanatorium for persons from throughout the United States diagnosed with tuberculosis. After raising sufficient funds, the association purchased 10 acres (4.0 ha) of land in Duarte, California, a small town in the more aridSan Gabriel Valley, approximately 16 miles (26 km) east of downtown Los Angeles, and dubbed the property theLos Angeles Sanatorium. Opening January 11, 1914, the sanatorium originally consisted of two tents, one for patients and one for caregivers.[3]
The sanatorium was nicknamed "the city of hope", and grew in size for several decades, continuing to raise funds, construct permanent facilities, hire doctors and treat increasing numbers of patients. Treating tuberculosis remained the sanatorium's focus until after World War II, whenantibiotics for tuberculosis were discovered.
With tuberculosis becoming less prevalent, executive sanatorium directorSamuel H. Golter began an initiative in 1946 to transform the sanatorium into a full medical center, supported by a research institute and post-graduate education.[4] The Los Angeles Sanatorium officially changed its name to City of Hope National Medical Center in 1949. City of Hope's research institute was formally established in 1952. TheCity of Hope Graduate School of Biological Sciences was eventually chartered in 1993, and changed its name to theIrell & Manella Graduate School of Biological Sciences in 2009.
From 1953 to 1985, under executive director Ben Horowitz, City of Hope grew further in size and became best known for its cancer research and treatment programs. Horowitz raised City of Hope's annual average operating budget from $600,000 to more than $100 million during his tenure.[5]
In 1981, the National Cancer Institute designated City of Hope a "Clinical Cancer Research Center". In 1983, theArnold and Mabel Beckman Foundation awarded City of Hope a $10 million grant to establish theBeckman Research Institute of City of Hope; the Beckman Research Institute of City of Hope is now City of Hope's research moniker, and is one of six institutes/centers established by the Beckman Foundation in the United States.
From 1983 to the present, City of Hope continued to grow, expanding its Duarte campus with additional patient care, research and support facilities. City of Hope also operates a network of community practice clinics throughout Southern California.
City of Hope acquiredCancer Treatment Centers of America in 2022 and began operating the facilities as City of Hope in 2023.[6]
City of Hope's institutional goals are theprevention, treatment andcure of cancer and other life-threatening diseases, includingdiabetes andHIV/AIDS. As such, City of Hope's programs include the fields ofbrain,breast,gastrointestinal,gynecologic,thoracic andurologic cancers, as well asleukemia,lymphoma, and diabetes. City of Hope has been designated aComprehensive Cancer Center by the National Cancer Institute, a branch of theNational Institutes of Health.
City of Hope is abench to bedside institution, with investments in basic, translational and clinical research. Faculty, residents and fellows conductbiomedical research,treat patients and educate medical professionals with the medical center serving as ateaching hospital.
Industrial, institutional, and National Cancer Institute-sponsored externalpeer-reviewedclinical trials are conducted at City of Hope.[7]
In 1978, City of Hope researchersArthur Riggs andKeiichi Itakura, working withHerbert Boyer of San Francisco–basedbiotechnologycorporationGenentech, Inc., became the first scientists to producesynthetic human insulin.[8] City of Hope licensed patents based on Riggs's and Itakura's work to Genentech. On August 13, 1999, City of Hope sued Genentech for allegedly cheating it out of its fair share of the profits from products based on the Riggs-Itakura patents. On April 24, 2008, theSupreme Court of California affirmed the jury's award of $300 million in contractual damages to City of Hope but reversed the award of $200 million in punitive damages.[9]
On January 13, 2011, City of Hope performed its 10,000thhematopoietic stem cell transplantation, which includes transplants ofbone marrow,peripheral blood stem cells collected byapheresis, andumbilical cord stem cells.[10]
By 2016, this has grown to over 13,000 stem cell transplants.
City of Hope is a founding member of theNational Comprehensive Cancer Network (NCCN), a non-profit alliance of 21 U.S. cancer centers. The NCCN publishes clinical practice guidelines for oncological treatment among its member institutions. Member institutions include City of Hope, The University of TexasMD Anderson Cancer Center,St. Jude Children's Research Hospital/University of Tennessee Cancer Institute,Fox Chase Cancer Center inPhiladelphia, Pennsylvania,Fred Hutchinson Cancer Research Center inSeattle, Washington, and 16 others.
City of Hope's main campus in Duarte has several treatment facilities for inpatient and outpatient care, including the Helford Clinical Research Hospital, Michael Amini Transfusion Medicine Center, the Geri and Richard Brawerman Center for Ambulatory Care and the Women's Center.
In addition to the Duarte facilities, City of Hope has treatment facilities across Southern California, Georgia, Illinois and Arizona.
Southern California community practice clinics are located in Antelope Valley, Arcadia, Corona, Glendale, Glendora, Huntington Beach, Irvine Sand Canyon, Long Beach, Mission Hills, Newport Beach, Palmdale, Pasadena, Riverside, San Bernardino, Santa Clarita, Sherman Oaks, Simi Valley, South Bay, South Pasadena, Temecula, Thousand Oaks, Torrance, Upland, West Covina, West Hills and Wildomar.[11]
City of Hope is building a $200 million, six-story cancer hospital, which will anchor its Lennar Foundation Cancer Center in Irvine, in Orange County. The center is slated to open in 2025.[12]
City of Hope is accredited by the Joint Commission, a private body which accredits over 17,000 health care organizations and programs in the United States.
Beckman Research Institute of City of Hope is one of six research facilities established by funding from theArnold and Mabel Beckman Foundation. Its primary focus is research in the areas ofcancer,diabetes, andHIV/AIDS. The institute shelters the City of HopeIrell & Manella Graduate School of Biological Sciences.
Research conducted at the institute has contributed to discoveries in the areas ofrecombinant DNA technology,gene therapy andmonoclonal antibodies.[citation needed]
City of Hope Center forBiomedicine &Genetics is a manufacturing facility specializing in the production ofpharmaceutical-grade materials. The center also assistsclinical investigators withtranslational research and clinical trials.
The graduate school at City of Hope; the school is housed within the Arnold and Mabel Beckman Center for Cancer Immunotherapeutics & Tumor Immunology.
City of Hope has 40 temporary, on-site residential housing units for patients and their caregivers, with integratedhospice andpalliative care.
City of Hope secures funding from a mixture of sources, including patient revenue, private donations, foundation support and federal research grants.
Annualfundraising events include Walk for Hope (a multi-citycharity fundraising walk), Concert for Hope (a fundraising concert featuring celebrity musicians), and the City of Hope CelebritySoftball Challenge, held inNashville, Tennessee.
City of Hope maintains eight regional fundraising offices in various cities throughout the United States, includingPalm Desert,Phoenix,San Diego,San Francisco, Seattle,Chicago, Philadelphia, andFt. Lauderdale, Florida.
The hospital also fundraises using giving days. In 2016, Doctors' Day allowed patients to thank doctors by giving in their name. More than $9000 was raised through 60 gifts. In 2017, City of Hope was planning a Bone Marrow Transplant Reunion Day and Survivors Day.[13] The hospital also participates in #GivingTuesday. In 2015, the first time the hospital used the fundraiser, almost $120,000 were raised from 681 gifts. In 2016, those numbers rose to almost $200,000 from more than 1500 gifts.[13] In January 2017 City of Hope received a donation of more than $50 million to establish the Wanek Family Project for Type 1 Diabetes at City of Hope.[14]
City of Hope is affiliated with the following institutions:
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