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CD3D

From Wikipedia, the free encyclopedia
Protein-coding gene in humans

CD3D
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

1XIW

Identifiers
AliasesCD3D, CD3-DELTA, IMD19, T3D, CD3d molecule, CD3 delta subunit of T-cell receptor complex, CD3DELTA
External IDsOMIM:186790;MGI:88331;HomoloGene:585;GeneCards:CD3D;OMA:CD3D - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for CD3D
Genomic location for CD3D
Band11q23.3Start118,339,075bp[1]
End118,342,705bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for CD3D
Genomic location for CD3D
Band9 A5.2|9 24.84 cMStart44,893,084bp[2]
End44,898,637bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • thymus

  • granulocyte

  • lymph node

  • appendix

  • blood

  • spleen

  • epithelium of nasopharynx

  • testicle

  • mucosa of ileum

  • bone marrow
Top expressed in
  • thymus

  • mesenteric lymph nodes

  • blood

  • spleen

  • granulocyte

  • subcutaneous adipose tissue

  • pharynx

  • right lung lobe

  • spermatid

  • superior surface of tongue
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

915

12500

Ensembl

ENSG00000167286

ENSMUSG00000032094

UniProt

P04234

P04235

RefSeq (mRNA)

NM_001040651
NM_000732

NM_013487

RefSeq (protein)

NP_000723
NP_001035741

NP_038515

Location (UCSC)Chr 11: 118.34 – 118.34 MbChr 9: 44.89 – 44.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

T-cell surface glycoprotein CD3 delta chain is aprotein that in humans is encoded by theCD3Dgene.[5]

Interactions

[edit]

CD3D has been shown tointeract withCD8A.[6]

See also

[edit]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000167286 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000032094 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^"Entrez Gene: CD3D CD3d molecule, delta (CD3-TCR complex)".
  6. ^Doucey MA, Goffin Laurence, Naeher Dieter, Michielin Olivier, Baumgärtner Petra, Guillaume Philippe, Palmer Ed, Luescher Immanuel F (Jan 2003)."CD3 delta establishes a functional link between the T cell receptor and CD8".J. Biol. Chem.278 (5). United States:3257–64.doi:10.1074/jbc.M208119200.ISSN 0021-9258.PMID 12215456.

Further reading

[edit]

External links

[edit]
  • HumanCD3D genome location andCD3D gene details page in theUCSC Genome Browser.
  • Overview of all the structural information available in thePDB forUniProt:P04234 (T-cell surface glycoprotein CD3 delta chain) at thePDBe-KB.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human T-cell surface glycoprotein CD3 delta chain (CD3D)
PDB gallery
  • 1xiw: Crystal structure of human CD3-e/d dimer in complex with a UCHT1 single-chain antibody fragment
    1xiw: Crystal structure of human CD3-e/d dimer in complex with a UCHT1 single-chain antibody fragment

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

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