Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This gene encodes an aquaporin which functions as both a molecular water channel protein and as a non-selective cation channel gated by cyclic guanosine monophosphate (cGMP).[7] It is a homotetramer with six bilayer spanning domains andN-glycosylation sites. The AQP1 monomer consists of six transmembrane alpha helices that are connected by five loops (A to E).[8] The protein physically resembles channel proteins and is abundant in erythrocytes and renal tubes. The gene encoding this aquaporin is a possible candidate for disorders involving imbalance in ocular fluid movement.[9]
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