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| AHFS/Drugs.com | International Drug Names |
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| Pharmacokinetic data | |
| Metabolism | N-demethylation[1] |
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| ECHA InfoCard | 100.000.332 |
| Chemical and physical data | |
| Formula | C13H17N3O |
| Molar mass | 231.299 g·mol−1 |
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Aminophenazone (oraminopyrine, amidopyrine, Pyramidon) is a non-narcoticanalgesic substance. It is apyrazolone and a derivative ofphenazone, which also has anti-inflammatory andantipyretic properties. While inexpensive and effective, especially in the treatment ofrheumatism, the drug carries a serious risk of severe and sometimes fatal side-effects, includingagranulocytosis.[citation needed] While its production and use have been banned in many countries, including France, Thailand, India and Japan, it is still sometimes used in the developing world.[citation needed]
A breath test with13C-labeled aminopyrine has been used as a non-invasive measure ofcytochrome P-450 metabolic activity in liver-function tests.[1] It is also used in measuring the total body water in the human body system.[2]
Aminophenazone was first synthesized byFriedrich Stolz andLudwig Knorr in the late nineteenth century, and sold as an anti-fever medicine known as Pyramidon byHoechst AG from 1897 until its eventual replacement[when?] by the saferpropyphenazone molecule.
Symptoms of exposure to this compound include:[3]
Agranulocytosis often occurs. Ingestion may cause central nervous system stimulation, vomiting, convulsions,cyanosis,tinnitus,leukopenia, kidney damage and coma. Ingestion may also lead to nausea, mental disturbances,methemoglobinemia, chocolate-colored blood, dizziness, epigastric pain, difficulty in hearing, thready pulse and liver damage.
Other symptoms reported via ingestion includehemolytic anemia,porphyria and severe gastrointestinal bleeding.Bone marrow depression also occurs. Rare eye effects includeacute transient myopia.
Chronic symptoms include:
When heated to decomposition this compound emits toxic fumes ofnitrogen oxides.
Amidopyrine is metabolized by demethylation and acetylation. Amidopirina metabolites are 4-aminoantipyrine, metilaminoantipirin, rubazonovaya and metilrubazonovaya acid. These acids have a reddish color. At high amidopirine doses, urine can have a reddish brown coloration, due to the presence in the urine of these acid markers.[4]
Hospital Universitario Ramón y Cajal in Madrid, Spain was built as a center for specialized surgery, apanacea for the ills of the health system in Madrid.Locals hence nicknamed itel piramidón.[5]
De acuerdo con todo ello, el Ramón y Cajal comenzó a ser esperado como la gran panacea que tenía que resolver gran parte de los problemas hospitalarios madrileños. Por ello, alguien pensó que, siguiendo con los términos médicos, el citado centro venía a ser a la sanidad madrileña como el Piramidón -un antipirético muy utilizado para eliminar los síntomas de la enfermedad, aunque no la enfermedad en sí- a cualquier enfermo. De ahí a que el Centro Ramón y Cajal pasara ser conocido por todos como el Piramidón no medió ni un paso.
