α2-adrenergic receptors include 3 highly homologous subtypes: α2A, α2B, and α2C. These receptors have a critical role in regulatingneurotransmitter release fromsympathetic nerves and from adrenergic neurons in thecentral nervous system. Studies in mice revealed that both the α2A and α2C subtypes were required for normalpresynaptic control of transmitter release from sympathetic nerves in theheart and from central noradrenergic neurons; the α2A subtype inhibited transmitter release at high stimulation frequencies, whereas the α2C subtype modulated neurotransmission at lower levels of nerve activity.[6]
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"α2A-adrenoceptor".IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived fromthe original on 2015-04-02. Retrieved2008-11-25.
