Protein-coding gene in the species Homo sapiens
AP-4 complex subunit beta-1 is aprotein that in humans is encoded by theAP4B1 gene .[ 5] [ 6]
The heterotetrameric adaptor protein (AP) complexes sort integral membrane proteins at various stages of the endocytic and secretory pathways. AP4 is composed of 2 large chains, beta-4 (AP4B1, this protein) and epsilon-4 (AP4E1 ), a medium chain, mu-4 (AP4M1 ), and a small chain, sigma-4 (AP4S1 )[ 6]
AP4B1 has been shown tointeract withAP4M1 .[ 7]
AP4-complex-mediated trafficking plays a crucial role in brain development and functioning.[ 8] [ 9]
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