Pituitary adenylate cyclase-activating polypeptide type I receptor also known asPAC1, is aprotein that in humans is encoded by theADCYAP1R1gene.[5] This receptor bindspituitary adenylate cyclase activating peptide.[6][7]
PAC1 is a membrane-associated protein and shares significant homology with members of theG-protein coupled class Bglucagon/secretin receptor family.[8] This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled toadenylate cyclase.Alternative splicing of two exons of this gene generates four major splice variants, but their full-length nature has not been determined.[5] PAC1 is expressed in theadrenal medulla,pancreatic acini,uterus,myenteric plexus andbrain.[9][10][11] It is also expressed in thetrigeminal,otic andsuperior cervical ganglia (prejunctional) and cerebral arteries (postjunctional).[12]
This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.
