4-Hydroxyphenylpyruvic acid

Names
Preferred IUPAC name 3-(4-Hydroxyphenyl)-2-oxopropanoic acid
Other names 4-Hydroxyphenylpyruvate p-Hydroxyphenylpyruvic acid p-Hydroxyphenylpyruvate
Identifiers
CAS Number	156-39-8 Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:15999 Y
ChEMBL	ChEMBL607712 Y
ChemSpider	954 Y
DrugBank	DB07718 Y
ECHA InfoCard	100.005.322
IUPHAR/BPS	6629
KEGG	C01179 Y
PubChemCID	979
UNII	0YP1694WNQ Y
CompTox Dashboard(EPA)	DTXSID80166017
InChI InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13) Y Key: KKADPXVIOXHVKN-UHFFFAOYSA-N Y InChI=1/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13) Key: KKADPXVIOXHVKN-UHFFFAOYAH
SMILES O=C(O)C(=O)Cc1ccc(O)cc1
Properties
Chemical formula	C9H8O4
Molar mass	180.157 g/mol
Melting point	219–220 °C (426–428 °F; 492–493 K)
Hazards
GHS labelling:
Pictograms	[1]
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

4-Hydroxyphenylpyruvic acid (4-HPPA) is an intermediate in the metabolism of the amino acidphenylalanine. The aromatic side chain of phenylalanine is hydroxylated by the enzymephenylalanine hydroxylase to formtyrosine. The conversion from tyrosine to 4-HPPA is in turn catalyzed bytyrosine aminotransferase.^[2] Additionally, 4-HPPA can be converted tohomogentisic acid which is one of the precursors toochronotic pigment.^[3]

It is an intermediary compound in the biosynthesis ofscytonemin.

• 4-Hydroxyphenylpyruvate dioxygenase

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