A homozygous missense mutation in humanKLOTHO causes severe tumoral calcinosis.

TheKlotho family of two receptor proteins is located on the surface of cells of specific tissues.

TheKlotho protein, is found on the surfaces of cells in specific tissues.

Other compounds presented demethylating activity, for example, Rhein, a plant-derived anthraquinone which displays strong antifibrotic properties in the experimental model of UUO, probably by reverseKlotho DNA hypermethylation [54] (Figure 1).

Xue et al., "Klotho down-regulates Egr-1 by inhibiting TGF-[beta]1/Smad3 signaling in high glucose treated human mesangial cells," Biochemical and Biophysical Research Communications, vol.

Modert et al., "Genetic Ablation of Fgf23 orKlotho Does not Modulate Experimental Heart Hypertrophy Induced by Pressure Overload," Scientific Reports, vol.

The purpose of this study was to: 1) observe the in vitro effects of 10, 100, and 1000 nM concentrations of calcitriol on VSMC calcification in the presence of normal and high phosphate, 2) examine the surface morphology and protein expression of VSMCs given 100 nM calcitriol in the presence of normal and high phosphate, and 3) observe the in vitro effects of combinations of calcitriol, FGF-23, and solubleklotho on VSMC calcification in the presence of high phosphate.

Lewis et al., "Klotho and smoking--an interplay influencing the skeletal muscle function deficits that occur in COPD," Respiratory Medicine, vol.

Nihei, "Oxidative stress decreasesklotho expression in a mouse kidney cell line," Nephron Experimental Nephrology, vol.

Now, evidence is mounting that the protein,klotho, may have similar effects on humans, triggering a search for ways to boost levels of this beneficial molecule in older adults.