Overview
This journal presents a forum for the publication of papers in the rapidly growing area of Purinergic Signalling (through purines and pyrimidines), with its exceptionally wide spectrum of signalling functions in health and disease. Coverage includes original articles, reviews, hot topics and controversies, and meeting reports.
There is both short-term purinergic signalling in transmission and secretion and long-term (trophic) signalling in controlling cell proliferation, differentiation, motility and death in development and regeneration. At the molecular level, rapid progress has been made in understanding the mechanisms of nucleotide and nucleoside release, their extracellular metabolism, the intracellular signalling cascades elicited by receptor activation and the cross-talk with other essential signalling pathways. In addition to basic research into the roles of purines and pyrimidines in physiological conditions, a recent emphasis is on translational research and the therapeutic opportunities concerning purinergic signalling.
- Editor-in-Chief
- Charles Kennedy
Journal metrics
- Journal Impact Factor
- 2.4 (2024)
- 5-year Journal Impact Factor
- 2.8 (2024)
- Submission to first decision (median)
- 6 days
- Downloads
- 298.3k (2024)
Calls for papers
Collection
Purinergic Signalling- A Perspective from China (III)
After two very successful special issues, we open for submissions the third edition of this collection.
- Status
- Open for submissions
- Submission deadline
- 30 September 2026
Collection
A tribute to Francesco di Virgilio
We are organising a Special Issue in Purinergic Signalling in honour and in loving memory of Francesco di Virgilio, who died suddenly on September...
- Status
- Open for submissions
- Submission deadline
- 30 June 2026
Collection
P2X receptors as therapeutic targets: a European perspective
P2X receptors (P2XRs) are ATP-gated ion channels involved in intercellular communication with an established role in neurodegeneration, infection,...
- Status
- Open for submissions
- Submission deadline
- 31 December 2025
Latest articles
Blockage of P2X7 receptor activation attenuated bone loss in ligature-induced model of periodontitis in rats
- Nadine Linhares
- Marco Aurelio Teófilo
- Paula Goes
Research 29 September 2025
Breast cancer patients present pro-tumor biomarkers related to purinergic signaling and oxidative stress
- Eduarda Valcarenghi Jabonski
- Simone Luciana Triquez
- Sarah Franco Vieira de Oliveira Maciel
Methodology 02 September 2025
Editorial: Purinergic signalling—a perspective from China (II)
- Yong Tang
- Peter Illes
Correspondence 29 August 2025 Pages: 1009 - 1012The P2X7 receptor in leukemia: pathological mechanisms and therapeutic potential
- Yanwen Xue
- Xiaoxiang Peng
- Ronglan Zhao
Review 22 August 2025
Astrocytes: crucial transducers that convert norepinephrine inputs to ATP signaling in the brain
- Yuto Kubota
- Eiji Shigetomi
- Schuichi Koizumi
Journal Club 19 August 2025
Journal updates
The Purine Club on LinkedIn
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Tributes and memories to Professor Geoff Burnstock
Obituary:Professor Dr. Geoffrey Burnstock (1929–2020)
Professor Geoffrey Burnstock, a great luminary in science and the founder of our field of purinergic signalling, sadly died peacefully in Melbourne, Australia, on the 2nd of June, 2020, at the age of 91.Purinergic Signalling, the journal that he founded and led for so many years, are creating a page on its website that will be dedicated to your tributes to and memories of Geoff. Please share these by emailing them to Dr. Charles Kennedy, deputy Editor-in-Chief, Purinergic Signalling, atc.kennedy@strath.ac.uk by November 1st 2020.
Journal Club
Purinergic Signalling has introduced a new type of article,Journal Club, that comprises a short review of recent, important papers in our field that have been published in other major scientific journals, such as Nature and Science. Please see thePDF file for details.
Call for Papers: A tribute to Francesco di Virgilio
We are organising a Special Issue inPurinergic Signalling in honour and in loving memory of Francesco di Virgilio, who died suddenly on September 22nd 2024. Francesco was one of the giants of purinergic signalling and made many important contributions to the field. The guest editors invite submissions in the form of original contributions or reviews to this issue.
Submission deadline: 30th June, 2026
Journal information
- Electronic ISSN
- 1573-9546
- Print ISSN
- 1573-9538
- Abstracted and indexed in
- BIOSIS
- Baidu
- Biological Abstracts
- CLOCKSS
- CNKI
- CNPIEC
- Chemical Abstracts Service (CAS)
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- Japanese Science and Technology Agency (JST)
- Medline
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- Norwegian Register for Scientific Journals and Series
- OCLC WorldCat Discovery Service
- Pathway Studio
- Portico
- ProQuest
- PubMedCentral
- Reaxys
- SCImago
- SCOPUS
- Science Citation Index Expanded (SCIE)
- TD Net Discovery Service
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- eLibrary.ru
- © Springer Nature B.V.
