Bakuchiol, a meroterpene phenol, is naturally derived from the seeds and leaves of the plant Psoralea corylifolia and other botanical sources. It has garnered significant interest in scientific research due to its role as a functional analog of retinol, providing a basis for comparative studies on cellular signaling pathways without the typical irritations associated with retinoids. Bakuchiol′s mechanism of action involves modulating gene expression similarly to retinol, thereby regulating proteins critical for cell differentiation and proliferation. Its capacity to influence these pathways makes it particularly useful in studies aimed at understanding cellular aging processes and gene regulation mechanisms, especially in dermatological research. Furthermore, Bakuchiol has been utilized to explore its antioxidant properties, examining how it scavenges free radicals and protects cells from oxidative stress. This is pivotal for investigations into the molecular foundations of cellular defense mechanisms against environmental stressors. Bakuchiol′s application extends to studies on its anti-inflammatory properties, providing insights into its interactions with pathways involving nuclear factor-kappa B (NF-κB), a protein complex that plays a crucial role in managing cellular responses to inflammation. Through these research applications, Bakuchiol contributes to a broader understanding of molecular biology and biochemistry.

Appearance :

Oil

Physical State :

Liquid

Derived From :

Psoralea corylifolia

Solubility :

Soluble in DMSO, and 100% ethanol.

Storage :

Store at -20° C

Melting Point :

106.00° C (Predicted)

Boiling Point :

391.38° C (Predicted)

Density :

0.96 g/mL (Predicted)

Refractive Index :

n²⁰_D 1.56 (Predicted)

IC50 :

HeLa: IC₅₀ = 11 µM (human); AGS: IC₅₀ = 15.3 µM (human); T47D: IC₅₀ = 28.9 µM (human)

pK Values :

pK_a: 10.1 (Predicted)

PubChem CID :

MDL Number :

MFCD01707441

SMILES :

CC(=CCC[C@@](C)(C=C)/C=C/C1=CC=C(C=C1)O)C

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