Categories:Organic Chemistry
Organic Chemistry
Jonathan Clayden, Nick Geeves, Stuart Warren
Paperback, 1234 Pages
2nd Edition, 2012
ISBN: 978-0199270293
Oxford University Press
Description
A first and second year undergraduateorganic chemistry textbook,specifically geared to British and European courses and courses offered inbetter schools in North America. The emphasis is on clarity and understanding,with very careful explanations of difficult concepts, many examples related toeveryday life, and a fresh and student-friendly writing style.
Editorial Review
If there is a text book for organic chemistry, which I can recommendwithout restriction, then it is "Organic Chemistry" from the authorsClayden/Greeves/Warren/Wolters. There are several reasons for this:
The book accompanies the beginner in organic chemistry from the structureof the molecules, over NMR up to the topics for advanced, likeheterocycles and asymmetrical synthesis. A typical arrangement offunctional groups as seen in older text books does not occur. Thus,rather mechanisms and concepts of organic chemistry with risingdifficulties are explained. Therefore it can be seen , that a certainmechanism (e.g. theaddition to a carbonyl group) can be applied todifferent functional groups.
A large deficiency of comparable books are the given schemes, which mostlycontain "R groups". In this regard, "Clayden" is very practice-related.Thus, in the chapter "acidity, basicity and pKa", the base instabilityof theFmoc protective group is explained . Examples like the synthesisof the antibiotic ofloxacin are skillfully inserted later.
As very successful I call the marginal notes. Thus a mechanism isexplained again in another kind, or you receive hints, referring toearlier or later chapters, where you can find more information about thetopic. Marginal notes contain remarks like "TheFavorskii mechanism wanthelp you understand theRamberg-Baecklund reaction... ". The bookdoesn´t lead you in temptation of stubborn memorization, but doespromote interlaced thinking.
Interesting additions are, e.g. chapters about main group chemistry (S, B,Si...), "Organometallic Chemistry" and "The Chemistry of Life".Therefore the book is not only recommendable for lectures in organicchemistry, but also as a companion in biochemistry lectures.
Who "Clayden" possesses, has in lectures where alcohols, amines, carbonicacids and amides are strictly treated separately from each other,probably more or less to keep leafing back and forth and back again.However, this book has, compared with usual text books, to offer somepluses.
Beyond that, I recommend lecturers the acquisition of an "inspectioncopy". You should use this offer,
to promote organic knowledge in another way and to encourage interlacedthinking.
Contents
1 What is organic chemistry?
Organic Chemistry and this book
2 Organic structures
3 Determining organic structures
4 Structure of molecules
5 Organic reactions
6 Nucleophilic addition to the carbonyl group
7 Delocalization and conjugation
8 Acidity, basicity, and pKa
9 Using organometallic reagents to make C-C bonds
10 Conjugate addition
11 Proton nuclear magnetic resonance
12 Nucleophilic substitution at the carbonyl (C=O) group
13 Equilibria, rates, and mechanisms: summary of mechanistic principles
14 Nucleophilic substitution at C=O with loss of carbonyl oxygen
15 Review of spectroscopic methods
16 Stereochemistry
17 Nucleophilic substitution at saturated carbon
18 Conformational analysis
19 Elimination reactions
20 Electrophilic addition to alkenes
21 Formation and reactions of enols and enolates
22 Electrophilic aromatic substitution
23 Electrophilic alkenes
24 Chemoselectivity: selective reactions and protection
25Synthesis in action
26 Alkylation of enolates
27 Reactions of enolates with aldehydes and ketones: the aldol reaction
28 Acylation at carbon
29 Conjugate addition of enolates
30 Retrosynthetic analysis
31 Controlling the geometry of double bonds
32 Determination of stereochemistry by spectroscopic
33 Stereoselective reactions of cyclic compounds
34 Diastereoselectivity
35 Pericyclic reactions 1: cycloadditions
36 Pericyclic reactions 2: sigmatropic and electrocyclic reactions
37 Rearrangements
38 Fragmentation
39 Radical reactions
40 Synthesis and reactions of carbenes
41 Determining reaction mechanisms
42 Saturated heterocycles and stereoelectronics
43 Aromatic heterocycles 1: structures and reactions
44 Aromatic heterocycles 2: synthesis
45 Asymmetric synthesis
46 Organo-main-group chemistry I: sulfur
47 Organo-main-group chemistry II: boron, silicon, and tin
48 Organometallic chemistry
49 The chemistry of life
50 Mechanisms in biological chemistry
51 Natural products
52 Polymerization
53 Organic chemistry today
