Movatterモバイル変換

[0]ホーム
URL:

Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
Thehttps:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

NIH NLM Logo
Log inShow account info
Access keysNCBI HomepageMyNCBI HomepageMain ContentMain Navigation
pubmed logo
Advanced Clipboard
User Guide

Full text links

MDPI full text link MDPI Free PMC article
Full text links

Actions

Share

Review
.2017 Feb 9;22(2):257.
doi: 10.3390/molecules22020257.

β-Glucans: Relationships between Modification, Conformation and Functional Activities

Affiliations
Review

β-Glucans: Relationships between Modification, Conformation and Functional Activities

Qiang Wang et al. Molecules..

Abstract

β-glucan is a type of polysaccharide which widely exists in bacteria, fungi, algae, and plants, and has been well known for its biological activities such as enhancing immunity, antitumor, antibacterial, antiviral, and wound healing activities. The conformation of β-glucan plays a crucial role on its biological activities. Therefore, β-glucans obtained from different sources, while sharing the same basic structures, often show different bioactivities. The basic structure and inter-molecular forces of polysaccharides can be changed by modification, which leads to the conformational transformation in solution that can directly affect bioactivity. In this review, we will first determine different ways to modify β-glucan molecules including physical methods, chemical methods, and biological methods, and then reveal the relationship of the flexible helix form of the molecule chain and the helix conformation to their bioactivities. Last, we summarize the scientific challenges to modifying β-glucan's conformation and functional activity, and discuss its potential future development.

Keywords: conformation transformation; functional activities; modification; β-glucans.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Scheme of possible polysaccharide chain conformations in aqueous solution.
Figure 2
Figure 2
Atomic Force Microscope (AFM) image (a) and schematic representation of the lentinan solution at 25 °C (b). Adapted from [5], with permission from the American Chemical Society, Copyright 2008.
Figure 3
Figure 3
The AFM topology graph ofPleurotus geesteranus β-d-glucan at different magnifications at 4 °C (a) and 22 °C (b) (reproduced from [18] with permission from John Wiley and Sons, Copyright 2009).
Figure 4
Figure 4
Schematic representation of the different types of helical structures ofPleurotus geesteranus β-d-glucan (reproduced from [18] with permission from John Wiley and Sons, Copyright 2009).
Figure 5
Figure 5
Schematic depiction of the interaction between the phosphorylated pachymaran P-PCS3-II chain and receptors on the immune cell (reprinted fromCarbohydr. Polym.,78, Chen, X.; Xu, X.; Zhang, L.; Zeng, F., Chain conformation and anti-tumor activities of phosphorylated (1→3)-β-d-glucan fromPoria cocos, pp. 581–587, Copyright (2009), with permission from Elsevier [15]).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Wang Q., Liu H.Z., Zhong K. Review on the relationship of polysaccharide molecular chain conformation changes and bioactivities. Curr. Biotechnol. 2011:318–326. doi: 10.3969/j.issn.2095-2341.2011.05.03. - DOI
    1. Li S., Xu S., Zhang L.N. Advances in conformations and characterizations of fungi polysaccharides. Acta Polym. Sin. 2010:1359–1375. doi: 10.3724/SP.J.1105.2010.10232. - DOI
    1. McIntosh M., Stone B.A., Stanisich V.A. Curdlan and other bacterial (1→3)-d-glucanss. Appl. Microbiol. Biotechnol. 2005;68:163–173. doi: 10.1007/s00253-005-1959-5. - DOI - PubMed
    1. Todaro S., Sabatinoa M.A., Mangione M.R., Picone P., Giacinto M.L.D., Bulone D., Dispenza C. Temporal control of xyloglucan self-assembly into layered structures by radiation-induced degradation. Carbohydr. Polym. 2016;152:382–390. doi: 10.1016/j.carbpol.2016.07.005. - DOI - PubMed
    1. Wang X., Xu X., Zhang L. Thermally Induced Conformation Transition of Triple-Helical Lentinan in NaCl Aqueous Solution. J. Phys. Chem. B. 2008;112:10343–10351. doi: 10.1021/jp802174v. - DOI - PubMed

Publication types

MeSH terms

Substances

Related information

LinkOut - more resources

Full text links
MDPI full text link MDPI Free PMC article
Cite
Send To

NCBI Literature Resources

MeSHPMCBookshelfDisclaimer

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.

[8]ページ先頭
©2009-2025 Movatter.jp