Antioxidants and atherosclerotic heart disease
- PMID:9241131
- DOI: 10.1056/NEJM199708073370607
Antioxidants and atherosclerotic heart disease
Abstract
Epidemiologic studies have provided evidence of an inverse relation between coronary artery disease and antioxidant intake, and vitamin E supplementation in particular. The oxidative-modification hypothesis implies that reduced atherosclerosis is a result of the production of LDL that is resistant to oxidation, but linking the reduced oxidation of LDL to a reduction in atherosclerosis has been problematic. Several important additional mechanisms may underlie the role of antioxidants in preventing the clinical manifestations of coronary artery disease (Fig. 2). Specifically, there is evidence that plaque stability, vasomotor function, and the tendency to thrombosis are subject to modification by specific antioxidants. For example, cellular antioxidants inhibit monocyte adhesion, protect against the cytotoxic effects of oxidized LDL, and inhibit platelet activation. Furthermore, cellular antioxidants protect against the endothelial dysfunction associated with atherosclerosis by preserving endothelium-derived nitric oxide activity. We speculate that these mechanisms have an important role in the benefits of antioxidants.
Similar articles
- Vitamin E and cardiovascular disease.Saremi A, Arora R.Saremi A, et al.Am J Ther. 2010 May-Jun;17(3):e56-65. doi: 10.1097/MJT.0b013e31819cdc9a.Am J Ther. 2010.PMID:19451807Review.
- Effect of vitamin E, vitamin C and beta-carotene on LDL oxidation and atherosclerosis.Jialal I, Fuller CJ.Jialal I, et al.Can J Cardiol. 1995 Oct;11 Suppl G:97G-103G.Can J Cardiol. 1995.PMID:7585302Review.
- [The significance of ixidized low density lipoprotein in atherosclerosis].Hansen PR.Hansen PR.Ugeskr Laeger. 1996 May 6;158(19):2706-10.Ugeskr Laeger. 1996.PMID:8744072Review.Danish.
- [Antioxidant vitamins--significance for preventing cardiovascular diseases. Part 1. Oxidized low-density lipoproteins and atherosclerosis; antioxidant dietary supplementation--vitamin E].Andreeva-Gateva P.Andreeva-Gateva P.Vutr Boles. 2000;32(3):11-8.Vutr Boles. 2000.PMID:11688317Review.Bulgarian.
- Role of oxidative modifications in atherosclerosis.Stocker R, Keaney JF Jr.Stocker R, et al.Physiol Rev. 2004 Oct;84(4):1381-478. doi: 10.1152/physrev.00047.2003.Physiol Rev. 2004.PMID:15383655Review.
Cited by
- Fruit and vegetable consumption and hypertriglyceridemia: Korean National Health and Nutrition Examination Surveys (KNHANES) 2007-2009.Yuan C, Lee HJ, Shin HJ, Stampfer MJ, Cho E.Yuan C, et al.Eur J Clin Nutr. 2015 Nov;69(11):1193-9. doi: 10.1038/ejcn.2015.77. Epub 2015 May 27.Eur J Clin Nutr. 2015.PMID:26014266
- Reduced photoinhibition under low irradiance enhanced Kacip Fatimah (Labisia pumila Benth) secondary metabolites, phenyl alanine lyase and antioxidant activity.Ibrahim MH, Jaafar HZE.Ibrahim MH, et al.Int J Mol Sci. 2012;13(5):5290-5306. doi: 10.3390/ijms13055290. Epub 2012 Apr 25.Int J Mol Sci. 2012.PMID:22754297Free PMC article.
- Analysis of circulating lipid-phase micronutrients in humans by HPLC: review and overview of new developments.Lai JF, Franke AA.Lai JF, et al.J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Jul 15;931:23-41. doi: 10.1016/j.jchromb.2013.04.031. Epub 2013 May 9.J Chromatogr B Analyt Technol Biomed Life Sci. 2013.PMID:23770735Free PMC article.Review.
- Associations between body mass index and the prevalence of low micronutrient levels among US adults.Kimmons JE, Blanck HM, Tohill BC, Zhang J, Khan LK.Kimmons JE, et al.MedGenMed. 2006 Dec 19;8(4):59.MedGenMed. 2006.PMID:17415336Free PMC article.
- Atorvastatin activates PPAR-gamma and attenuates the inflammatory response in human monocytes.Grip O, Janciauskiene S, Lindgren S.Grip O, et al.Inflamm Res. 2002 Feb;51(2):58-62. doi: 10.1007/BF02684000.Inflamm Res. 2002.PMID:11926313
Publication types
MeSH terms
Substances
Related information
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical