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.2021 Jul 2;49(W1):W293-W296.
doi: 10.1093/nar/gkab301.

Interactive Tree Of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation

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Interactive Tree Of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation

Ivica Letunic et al. Nucleic Acids Res..

Abstract

The Interactive Tree Of Life (https://itol.embl.de) is an online tool for the display, manipulation and annotation of phylogenetic and other trees. It is freely available and open to everyone. iTOL version 5 introduces a completely new tree display engine, together with numerous new features. For example, a new dataset type has been added (MEME motifs), while annotation options have been expanded for several existing ones. Node metadata display options have been extended and now also support non-numerical categorical values, as well as multiple values per node. Direct manual annotation is now available, providing a set of basic drawing and labeling tools, allowing users to draw shapes, labels and other features by hand directly onto the trees. Support for tree and dataset scales has been extended, providing fine control over line and label styles. Unrooted tree displays can now use the equal-daylight algorithm, proving a much greater display clarity. The user account system has been streamlined and expanded with new navigation options and currently handles >1 million trees from >70 000 individual users.

© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

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Figures

Graphical Abstract
Graphical Abstract
iTOL: an online tool for the tree display and annotation.
Figure 1.
Figure 1.
iTOL’s user interface. A phylogenetic tree annotated with several datasets is displayed, highlighting several new features. Internal tree scale level lines were individually styled, and an axis was added. Manual annotation drawing tools were used to add the taxonomic domain labels outside the tree. Manual annotations can be interactively scaled, rotated and repositioned.
Figure 2.
Figure 2.
MEME motif dataset visualization in iTOL. (A) Dataset display: an XML file created by the MEME suite has been dropped onto the tree and visualized with a style similar to the default MEME results page. (B) MEME motif logo: zoomed in detail of the dataset, with two motifs displayed as MEME sequence logos, showing the individual residue probabilities as different sized letters.
See this image and copyright information in PMC

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