.2019 Aug;22(3):129-133.

doi: 10.1136/ebmental-2019-300097. Epub 2019 Jun 28.

Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets

Ruth H Jack¹, Chris Hollis^{2 3 4}, Carol Coupland¹, Richard Morriss^{2 3 4}, Roger David Knaggs⁵, Andrea Cipriani⁶, Samuele Cortese^{2 7 8 9}, Julia Hippisley-Cox¹⁰

Affiliations

¹ Division of Primary Care, University of Nottingham, Nottingham, UK.
² Division of Psychiatry and Applied Psychology, University of Nottingham, Nottingham, UK.
³ National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham, UK.
⁴ National Institute for Health Research (NIHR) Mental Health MedTech Co-operative (MindTech), Nottingham, UK.
⁵ School of Pharmacy, University of Nottingham, Nottingham, UK.
⁶ Department of Psychiatry, University of Oxford, Oxford, UK.
⁷ Centre for Innovation in Mental Health, University of Southampton, Southampton, UK.
⁸ Clinical and Experimental Sciences (CNS and Psychiatry), University of Southampton, Southampton, UK.
⁹ Child Study Center, New York University, New York, NY, USA.
¹⁰ Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

PMID:31253602
PMCID: PMC6662952
DOI: 10.1136/ebmental-2019-300097

Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets

Ruth H Jack et al. Evid Based Ment Health.2019 Aug.

.2019 Aug;22(3):129-133.

doi: 10.1136/ebmental-2019-300097. Epub 2019 Jun 28.

Authors

Ruth H Jack¹, Chris Hollis^{2 3 4}, Carol Coupland¹, Richard Morriss^{2 3 4}, Roger David Knaggs⁵, Andrea Cipriani⁶, Samuele Cortese^{2 7 8 9}, Julia Hippisley-Cox¹⁰

Affiliations

¹ Division of Primary Care, University of Nottingham, Nottingham, UK.
² Division of Psychiatry and Applied Psychology, University of Nottingham, Nottingham, UK.
³ National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham, UK.
⁴ National Institute for Health Research (NIHR) Mental Health MedTech Co-operative (MindTech), Nottingham, UK.
⁵ School of Pharmacy, University of Nottingham, Nottingham, UK.
⁶ Department of Psychiatry, University of Oxford, Oxford, UK.
⁷ Centre for Innovation in Mental Health, University of Southampton, Southampton, UK.
⁸ Clinical and Experimental Sciences (CNS and Psychiatry), University of Southampton, Southampton, UK.
⁹ Child Study Center, New York University, New York, NY, USA.
¹⁰ Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

PMID:31253602
PMCID: PMC6662952
DOI: 10.1136/ebmental-2019-300097

Abstract

Introduction: Increasing numbers of children and young people (CYP) are receiving prescriptions for antidepressants. This is the protocol of a study aiming to describe the trends and variation in antidepressant prescriptions in CYP in England, and to examine the indications for the prescriptions recorded and whether there was contact with secondary care specialists on or around the time of the first antidepressant prescription.

Methods and analysis: All eligible CYP aged between 5 and 17 years in 1998-2017 from the QResearch primary care database will be included. Incidence and prevalence rates of any antidepressant prescription in each year will be calculated. We will examine four different antidepressant classes: selective serotonin reuptake inhibitors, tricyclic and related antidepressants, serotonin and norepinephrine reuptake inhibitors and other antidepressants, as well as for individual drugs. Linked primary and secondary care data (hospital episode statistics) in the year before and up to 6 months after the first antidepressant prescription will be examined for CYP whose first antidepressant prescription was in 2006-2017. Whether there were records of indications and being seen by psychiatric or paediatric specialists will be identified. Trends over time and differences by region, deprivation and ethnicity will be examined using Poisson regression.

Discussion: This large, population-based study will give an up-to-date picture of antidepressant prescribing in CYP and identify any variation. Understanding what indications are recorded when CYP are being prescribed antidepressants, and whether this was done in partnership with secondary care specialists, will provide evidence of whether appropriate guidelines are being followed.

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Conflict of interest statement

Competing interests: JHC is a professor of clinical epidemiology and general practice at the University of Oxford and co-director of QResearch®—a not-for-profit organisation which is a joint partnership between the University of Oxford and Egton Medical Information Systems (the leading commercial supplier of IT for 60% of general practices in the UK). JHC is also a paid director of ClinRisk Ltd which produces open and closed source software to ensure the reliable and updatable implementation of clinical risk equations within clinical computer systems to help improve patient care. AC is the EiC for EBMH and SC is an associate editor for EBMH. This work and any views expressed within it are solely those of the co-authors, and not of any affiliated bodies or organisations.

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Incidence and prevalence of primary care antidepressant prescribing in children and young people in England, 1998-2017: A population-based cohort study.
Jack RH, Hollis C, Coupland C, Morriss R, Knaggs RD, Butler D, Cipriani A, Cortese S, Hippisley-Cox J.Jack RH, et al.PLoS Med. 2020 Jul 22;17(7):e1003215. doi: 10.1371/journal.pmed.1003215. eCollection 2020 Jul.PLoS Med. 2020.PMID:32697803Free PMC article.

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Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets

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Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets

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