Review
doi: 10.1128/JVI.00386-15. Epub 2015 Apr 15.Timing Is Everything: Coordinated Control of Host Shutoff by Influenza A Virus NS1 and PA-X Proteins
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- PMID:25878098
- PMCID: PMC4468473
- DOI: 10.1128/JVI.00386-15
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Review
Timing Is Everything: Coordinated Control of Host Shutoff by Influenza A Virus NS1 and PA-X Proteins
Denys A Khaperskyy et al. J Virol.2015 Jul.
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Abstract
Like all viruses, influenza viruses (IAVs) use host translation machinery to decode viral mRNAs. IAVs ensure efficient translation of viral mRNAs through host shutoff, a process whereby viral proteins limit the accumulation of host proteins through subversion of their biogenesis. Despite its small genome, the virus deploys multiple host shutoff mechanisms at different stages of infection, thereby ensuring successful replication while limiting the communication of host antiviral responses. In this Gem, we review recent data on IAV host shutoff proteins, frame the outstanding questions in the field, and propose a temporally coordinated model of IAV host shutoff.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.
Figures
A temporal model of influenza A virus host shutoff. See the text for details. dsRNA, double-stranded RNA; eIF4F, eukaryotic translation initiation factor 4F.
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