Cell-penetrating Peptide-mediated therapeutic molecule delivery into the central nervous system
- PMID:23997754
- PMCID: PMC3637673
- DOI: 10.2174/1570159X11311020006
Cell-penetrating Peptide-mediated therapeutic molecule delivery into the central nervous system
Abstract
The blood-brain barrier (BBB), a dynamic and complex barrier formed by endothelial cells, can impede the entry of unwanted substances - pathogens and therapeutic molecules alike - into the central nervous system (CNS) from the blood circulation. Taking into account the fact that CNS-related diseases are the largest and fastest growing unmet medical concern, many potential protein- and nucleic acid-based medicines have been developed for therapeutic purposes. However, due to their poor ability to cross the BBB and the plasma membrane, the above-mentioned bio-macromolecules have limited use in treating neurological diseases. Finding effective, safe, and convenient ways to deliver therapeutic molecules into the CNS is thus urgently required. In recent decades, much effort has been expended in the development of drug delivery technologies, of which cell-penetrating peptides (CPPs) have the most promising potential. The present review covers the latest advances in CPP delivery technology, and provides an update on their use in CNS-targeted drug delivery.
Keywords: Central nervous system; blood-brain barrier; cell-penetrating peptides; drug delivery..
Figures
Similar articles
- Brain penetrating peptides and peptide-drug conjugates to overcome the blood-brain barrier and target CNS diseases.Zhou X, Smith QR, Liu X.Zhou X, et al.Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2021 Jul;13(4):e1695. doi: 10.1002/wnan.1695. Epub 2021 Jan 20.Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2021.PMID:33470550Review.
- Cell-Penetrating Peptides: As a Promising Theranostics Strategy to Circumvent the Blood-Brain Barrier for CNS Diseases.Varnamkhasti BS, Jafari S, Taghavi F, Alaei L, Izadi Z, Lotfabadi A, Dehghanian M, Jaymand M, Derakhshankhah H, Saboury AA.Varnamkhasti BS, et al.Curr Drug Deliv. 2020;17(5):375-386. doi: 10.2174/1567201817666200415111755.Curr Drug Deliv. 2020.PMID:32294035Review.
- Peptides for trans-blood-brain barrier delivery.Blades R, Ittner LM, Tietz O.Blades R, et al.J Labelled Comp Radiopharm. 2023 Jul;66(9):237-248. doi: 10.1002/jlcr.4023. Epub 2023 Apr 20.J Labelled Comp Radiopharm. 2023.PMID:37002811Free PMC article.Review.
- Combination of cell-penetrating peptides with nanomaterials for the potential therapeutics of central nervous system disorders: a review.Zhang Y, Guo P, Ma Z, Lu P, Kebebe D, Liu Z.Zhang Y, et al.J Nanobiotechnology. 2021 Aug 23;19(1):255. doi: 10.1186/s12951-021-01002-3.J Nanobiotechnology. 2021.PMID:34425832Free PMC article.Review.
- Highly cationic cell-penetrating peptides affect the barrier integrity and facilitates mannitol permeation in a human stem cell-based blood-brain barrier model.Frøslev P, Franzyk H, Ozgür B, Brodin B, Kristensen M.Frøslev P, et al.Eur J Pharm Sci. 2022 Jan 1;168:106054. doi: 10.1016/j.ejps.2021.106054. Epub 2021 Oct 30.Eur J Pharm Sci. 2022.PMID:34728364
Cited by
- Novel approaches for the treatment of methicillin-resistant Staphylococcus aureus: Using nanoparticles to overcome multidrug resistance.Vanamala K, Tatiparti K, Bhise K, Sau S, Scheetz MH, Rybak MJ, Andes D, Iyer AK.Vanamala K, et al.Drug Discov Today. 2021 Jan;26(1):31-43. doi: 10.1016/j.drudis.2020.10.011. Epub 2020 Oct 20.Drug Discov Today. 2021.PMID:33091564Free PMC article.Review.
- A Simple Alternative to Stereotactic Injection for Brain Specific Knockdown of miRNA.Suryawanshi H, Sarangdhar MA, Vij M, Roshan R, Singh VP, Ganguli M, Pillai B.Suryawanshi H, et al.J Vis Exp. 2015 Dec 26;(106):e53307. doi: 10.3791/53307.J Vis Exp. 2015.PMID:26779762Free PMC article.
- A New Noncanonical Anionic Peptide That Translocates a Cellular Blood-Brain Barrier Model.Neves-Coelho S, Eleutério RP, Enguita FJ, Neves V, Castanho MARB.Neves-Coelho S, et al.Molecules. 2017 Oct 18;22(10):1753. doi: 10.3390/molecules22101753.Molecules. 2017.PMID:29057814Free PMC article.
- Cell-Penetrating Peptides as Valuable Tools for Nose-to-Brain Delivery of Biological Drugs.De Martini LB, Sulmona C, Brambilla L, Rossi D.De Martini LB, et al.Cells. 2023 Jun 16;12(12):1643. doi: 10.3390/cells12121643.Cells. 2023.PMID:37371113Free PMC article.Review.
- Systemic delivery to central nervous system by engineered PLGA nanoparticles.Cai Q, Wang L, Deng G, Liu J, Chen Q, Chen Z.Cai Q, et al.Am J Transl Res. 2016 Feb 15;8(2):749-64. eCollection 2016.Am J Transl Res. 2016.PMID:27158367Free PMC article.Review.
References
- Chen Y, Liu L. Modern methods for delivery of drugs across the blood-brain barrier. Adv. Drug. Deliv. Rev. 2011 doi: 10.1016/j.addr. 2011. 11. 010. - PubMed
- Cecchell R, Berezowski V, Lundquis S, Culot M, Renfte M, Dehouck MP, Fenart L. Modelling of the blood-brain barrier in drug discovery and development. Nat. Rev. Drug Discov. 2007;6:650–661. - PubMed
- Newton HB. Advances in strategies to improve drug delivery to brain tumors. Exp. Rev. Ther. 2006;6:1495–1509. - PubMed
- Brownlees J, Williams CH. Peptidases, peptides and the mammalian blood-brain barrier. J. Neurochem. 1993;60:1089–1096. - PubMed
LinkOut - more resources
Full Text Sources
Other Literature Sources