doi: 10.4161/auto.24877. Epub 2013 May 2.
AMPK connects energy stress to PIK3C3/VPS34 regulation
Affiliations
- PMID:23669030
- PMCID: PMC3722323
- DOI: 10.4161/auto.24877
Item in Clipboard
AMPK connects energy stress to PIK3C3/VPS34 regulation
Joungmok Kim et al. Autophagy.2013 Jul.
Display options
Format
Display options
Format
Abstract
The class III phosphatidylinositol (PtdIns)-3 kinase, PIK3C3/VPS34, forms multiple complexes and regulates a variety of cellular functions, especially in intracellular vesicle trafficking and autophagy. Even though PtdIns3P, the product of PIK3C3, is thought to be a critical membrane marker for the autophagosome, it is unclear how PIK3C3 is regulated in response to autophagy-inducing stimuli. A complexity of PIK3C3 biology is due in part to the existence of multiple complexes, of which the ATG14- or UVRAG-containing complexes play important roles in autophagy. We recently discovered differential regulation of distinct PIK3C3 complexes in response to energy starvation and showed a mechanism by which AMPK directly phosphorylates PIK3C3 and BECN1 to regulate non- and pro-autophagic PIK3C3 complexes, respectively.
Keywords: AMPK; ATG14; BECN1; VPS34 complexes; autophagy.
Figures
Figure 1. A proposed PIK3C3 regulatory mechanism in response to energy starvation. AMPK phosphorylates PIK3C3 and BECN1 to inhibit the nonautophagy PIK3C3 complex as well as activate the pro-autophagy PIK3C3 complex in response to energy starvation.
Comment on
- Kim J, Kim YC, Fang C, Russell RC, Kim JH, Fan W, et al. Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell. 2013;152:290–303. doi: 10.1016/j.cell.2012.12.016.
Similar articles
- Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy.Yuan HX, Russell RC, Guan KL.Yuan HX, et al.Autophagy. 2013 Dec;9(12):1983-95. doi: 10.4161/auto.26058.Autophagy. 2013.PMID:24013218Free PMC article.
- FoxO1-AMPK-ULK1 Regulates Ethanol-Induced Autophagy in Muscle by Enhanced ATG14 Association with the BECN1-PIK3C3 Complex.Hong-Brown LQ, Brown CR, Navaratnarajah M, Lang CH.Hong-Brown LQ, et al.Alcohol Clin Exp Res. 2017 May;41(5):895-910. doi: 10.1111/acer.13377. Epub 2017 Apr 5.Alcohol Clin Exp Res. 2017.PMID:28299793Free PMC article.
- Selective autophagy inhibition through disruption of the PIK3C3-containing complex I.Pavlinov I, Salkovski M, Aldrich LN.Pavlinov I, et al.Autophagy. 2020 Aug;16(8):1547-1549. doi: 10.1080/15548627.2020.1786268. Epub 2020 Jul 3.Autophagy. 2020.PMID:32619130Free PMC article.
- Class III phosphatidylinositol 3-kinase complex I subunit NRBF2/Atg38 - from cell and structural biology to health and disease.Ohashi Y.Ohashi Y.Autophagy. 2021 Dec;17(12):3897-3907. doi: 10.1080/15548627.2021.1872240. Epub 2021 Jan 18.Autophagy. 2021.PMID:33459128Free PMC article.Review.
- Differential regulatory functions of three classes of phosphatidylinositol and phosphoinositide 3-kinases in autophagy.Yu X, Long YC, Shen HM.Yu X, et al.Autophagy. 2015;11(10):1711-28. doi: 10.1080/15548627.2015.1043076.Autophagy. 2015.PMID:26018563Free PMC article.Review.
Cited by
- Aspirin Recapitulates Features of Caloric Restriction.Pietrocola F, Castoldi F, Markaki M, Lachkar S, Chen G, Enot DP, Durand S, Bossut N, Tong M, Malik SA, Loos F, Dupont N, Mariño G, Abdelkader N, Madeo F, Maiuri MC, Kroemer R, Codogno P, Sadoshima J, Tavernarakis N, Kroemer G.Pietrocola F, et al.Cell Rep. 2018 Feb 27;22(9):2395-2407. doi: 10.1016/j.celrep.2018.02.024.Cell Rep. 2018.PMID:29490275Free PMC article.
- Decorin is an autophagy-inducible proteoglycan and is required for proper in vivo autophagy.Gubbiotti MA, Neill T, Frey H, Schaefer L, Iozzo RV.Gubbiotti MA, et al.Matrix Biol. 2015 Oct;48:14-25. doi: 10.1016/j.matbio.2015.09.001. Epub 2015 Sep 4.Matrix Biol. 2015.PMID:26344480Free PMC article.
- Regulation of immune response byS-1-propenylcysteine through autophagy-mediated protein degradation.Suzuki JI, Miki S, Ushijima M, Kodera Y.Suzuki JI, et al.Exp Ther Med. 2020 Feb;19(2):1570-1573. doi: 10.3892/etm.2019.8392. Epub 2019 Dec 27.Exp Ther Med. 2020.PMID:32010341Free PMC article.Review.
- Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes.Rostislavleva K, Soler N, Ohashi Y, Zhang L, Pardon E, Burke JE, Masson GR, Johnson C, Steyaert J, Ktistakis NT, Williams RL.Rostislavleva K, et al.Science. 2015 Oct 9;350(6257):aac7365. doi: 10.1126/science.aac7365.Science. 2015.PMID:26450213Free PMC article.
- Research progress on the relationship between autophagy and chronic complications of diabetes.Ge X, Wang L, Fei A, Ye S, Zhang Q.Ge X, et al.Front Physiol. 2022 Aug 8;13:956344. doi: 10.3389/fphys.2022.956344. eCollection 2022.Front Physiol. 2022.PMID:36003645Free PMC article.Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources