Schizophrenia, gluten, and low-carbohydrate, ketogenic diets: a case report and review of the literature
- PMID:19245705
- PMCID: PMC2652467
- DOI: 10.1186/1743-7075-6-10
Schizophrenia, gluten, and low-carbohydrate, ketogenic diets: a case report and review of the literature
Abstract
We report the unexpected resolution of longstanding schizophrenic symptoms after starting a low-carbohydrate, ketogenic diet. After a review of the literature, possible reasons for this include the metabolic consequences from the elimination of gluten from the diet, and the modulation of the disease of schizophrenia at the cellular level.
Similar articles
- Nutritional Deficiencies in Vegetarian, Gluten-Free, and Ketogenic Diets.Andrewski E, Cheng K, Vanderpool C.Andrewski E, et al.Pediatr Rev. 2022 Feb 1;43(2):61-70. doi: 10.1542/pir.2020-004275.Pediatr Rev. 2022.PMID:35102403Review.
- The Impact of Low-FODMAPs, Gluten-Free, and Ketogenic Diets on Gut Microbiota Modulation in Pathological Conditions.Reddel S, Putignani L, Del Chierico F.Reddel S, et al.Nutrients. 2019 Feb 12;11(2):373. doi: 10.3390/nu11020373.Nutrients. 2019.PMID:30759766Free PMC article.Review.
- Efficacy of low carbohydrate and ketogenic diets in treating mood and anxiety disorders: systematic review and implications for clinical practice.Dietch DM, Kerr-Gaffney J, Hockey M, Marx W, Ruusunen A, Young AH, Berk M, Mondelli V.Dietch DM, et al.BJPsych Open. 2023 Apr 17;9(3):e70. doi: 10.1192/bjo.2023.36.BJPsych Open. 2023.PMID:37066662Free PMC article.Review.
- Low-carbohydrate ketogenic diets, glucose homeostasis, and nonalcoholic fatty liver disease.Schugar RC, Crawford PA.Schugar RC, et al.Curr Opin Clin Nutr Metab Care. 2012 Jul;15(4):374-80. doi: 10.1097/MCO.0b013e3283547157.Curr Opin Clin Nutr Metab Care. 2012.PMID:22617564Free PMC article.Review.
- Low-carbohydrate ketogenic diets in body weight control: A recurrent plaguing issue of fad diets?Schutz Y, Montani JP, Dulloo AG.Schutz Y, et al.Obes Rev. 2021 Mar;22 Suppl 2:e13195. doi: 10.1111/obr.13195. Epub 2021 Jan 20.Obes Rev. 2021.PMID:33471427Review.
Cited by
- Nutrition, nutritional deficiencies, and schizophrenia: An association worthy of constant reassessment.Onaolapo OJ, Onaolapo AY.Onaolapo OJ, et al.World J Clin Cases. 2021 Oct 6;9(28):8295-8311. doi: 10.12998/wjcc.v9.i28.8295.World J Clin Cases. 2021.PMID:34754840Free PMC article.Review.
- The Current Status of the Ketogenic Diet in Psychiatry.Bostock EC, Kirkby KC, Taylor BV.Bostock EC, et al.Front Psychiatry. 2017 Mar 20;8:43. doi: 10.3389/fpsyt.2017.00043. eCollection 2017.Front Psychiatry. 2017.PMID:28373848Free PMC article.Review.
- Dysfunction in the coagulation system and schizophrenia.Hoirisch-Clapauch S, Amaral OB, Mezzasalma MA, Panizzutti R, Nardi AE.Hoirisch-Clapauch S, et al.Transl Psychiatry. 2016 Jan 5;6(1):e704. doi: 10.1038/tp.2015.204.Transl Psychiatry. 2016.PMID:26731441Free PMC article.Review.
- Metabolic Insights into Neuropsychiatric Illnesses and Ketogenic Therapies: A Transcriptomic View.Sahay S, Pulvender P, Rami Reddy MVSR, McCullumsmith RE, O'Donovan SM.Sahay S, et al.Int J Mol Sci. 2024 Jul 29;25(15):8266. doi: 10.3390/ijms25158266.Int J Mol Sci. 2024.PMID:39125835Free PMC article.
- Ketogenic diets in clinical psychology: examining the evidence and implications for practice.Laurent N, Bellamy EL, Hristova D, Houston A.Laurent N, et al.Front Psychol. 2024 Sep 26;15:1468894. doi: 10.3389/fpsyg.2024.1468894. eCollection 2024.Front Psychol. 2024.PMID:39391844Free PMC article.
References
- Yancy WS, Jr, Olsen MK, Guyton JR, Bakst RP, Westman EC. A low-carbohydrate, ketogenic diet versus a low-fat diet to treat obesity and hyperlipidemia: a randomized, controlled trial. Ann Intern Med. 2004;140:769–777. - PubMed
- Dohan FC, Harper EH, Clark MH, Rodrigue RB, Zigas V. Is schizophrenia rare if grain is rare? Biol Psychiatry. 1984;19:385–399. - PubMed
Related information
LinkOut - more resources
Full Text Sources