Review
doi: 10.1074/jbc.R700004200. Epub 2007 May 14.The interferons: 50 years after their discovery, there is much more to learn
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- DOI: 10.1074/jbc.R700004200
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Review
The interferons: 50 years after their discovery, there is much more to learn
Sidney Pestka. J Biol Chem..
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Abstract
The interferons (IFNs) and their receptors represent a subset of the class 2 alpha-helical cytokines that have been in chordates for millions of years. This brief review focuses on the discovery and purification of interferons, cloning of human IFN-alpha and IFN-beta, interferon receptors, activities and therapeutic uses of interferons, and the side effects of interferons.
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