doi: 10.1038/nm1523. Epub 2006 Dec 24.
Calreticulin exposure dictates the immunogenicity of cancer cell death
Michel Obeid 1, Antoine Tesniere, François Ghiringhelli, Gian Maria Fimia, Lionel Apetoh, Jean-Luc Perfettini, Maria Castedo, Grégoire Mignot, Theoharis Panaretakis, Noelia Casares, Didier Métivier, Nathanael Larochette, Peter van Endert, Fabiola Ciccosanti, Mauro Piacentini, Laurence Zitvogel, Guido Kroemer
Affiliations
- PMID:17187072
- DOI: 10.1038/nm1523
Item in Clipboard
Calreticulin exposure dictates the immunogenicity of cancer cell death
Michel Obeid et al. Nat Med.2007 Jan.
Display options
Format
Display options
Format
Abstract
Anthracyclin-treated tumor cells are particularly effective in eliciting an anticancer immune response, whereas other DNA-damaging agents such as etoposide and mitomycin C do not induce immunogenic cell death. Here we show that anthracyclins induce the rapid, preapoptotic translocation of calreticulin (CRT) to the cell surface. Blockade or knockdown of CRT suppressed the phagocytosis of anthracyclin-treated tumor cells by dendritic cells and abolished their immunogenicity in mice. The anthracyclin-induced CRT translocation was mimicked by inhibition of the protein phosphatase 1/GADD34 complex. Administration of recombinant CRT or inhibitors of protein phosphatase 1/GADD34 restored the immunogenicity of cell death elicited by etoposide and mitomycin C, and enhanced their antitumor effects in vivo. These data identify CRT as a key feature determining anticancer immune responses and delineate a possible strategy for immunogenic chemotherapy.
Comment in
- A 'good death' for tumor immunology.Storkus WJ, Falo LD Jr.Storkus WJ, et al.Nat Med. 2007 Jan;13(1):28-30. doi: 10.1038/nm0107-28.Nat Med. 2007.PMID:17206130No abstract available.
- Chemotherapy response of spontaneous mammary tumors is independent of the adaptive immune system.Ciampricotti M, Hau CS, Doornebal CW, Jonkers J, de Visser KE.Ciampricotti M, et al.Nat Med. 2012 Mar 6;18(3):344-6; author reply 346. doi: 10.1038/nm.2652.Nat Med. 2012.PMID:22395693No abstract available.
Similar articles
- Calreticulin exposure increases cancer immunogenicity.Clarke C, Smyth MJ.Clarke C, et al.Nat Biotechnol. 2007 Feb;25(2):192-3. doi: 10.1038/nbt0207-192.Nat Biotechnol. 2007.PMID:17287754No abstract available.
- A 'good death' for tumor immunology.Storkus WJ, Falo LD Jr.Storkus WJ, et al.Nat Med. 2007 Jan;13(1):28-30. doi: 10.1038/nm0107-28.Nat Med. 2007.PMID:17206130No abstract available.
- ERP57 membrane translocation dictates the immunogenicity of tumor cell death by controlling the membrane translocation of calreticulin.Obeid M.Obeid M.J Immunol. 2008 Aug 15;181(4):2533-43. doi: 10.4049/jimmunol.181.4.2533.J Immunol. 2008.PMID:18684944
- Molecular determinants of immunogenic cell death: surface exposure of calreticulin makes the difference.Chaput N, De Botton S, Obeid M, Apetoh L, Ghiringhelli F, Panaretakis T, Flament C, Zitvogel L, Kroemer G.Chaput N, et al.J Mol Med (Berl). 2007 Oct;85(10):1069-76. doi: 10.1007/s00109-007-0214-1. Epub 2007 May 22.J Mol Med (Berl). 2007.PMID:17891368Review.
- Ecto-calreticulin in immunogenic chemotherapy.Obeid M, Tesniere A, Panaretakis T, Tufi R, Joza N, van Endert P, Ghiringhelli F, Apetoh L, Chaput N, Flament C, Ullrich E, de Botton S, Zitvogel L, Kroemer G.Obeid M, et al.Immunol Rev. 2007 Dec;220:22-34. doi: 10.1111/j.1600-065X.2007.00567.x.Immunol Rev. 2007.PMID:17979837Review.
Cited by
- Radiation-induced loss of cell surface CD47 enhances immune-mediated clearance of human papillomavirus-positive cancer.Vermeer DW, Spanos WC, Vermeer PD, Bruns AM, Lee KM, Lee JH.Vermeer DW, et al.Int J Cancer. 2013 Jul;133(1):120-9. doi: 10.1002/ijc.28015. Epub 2013 Feb 12.Int J Cancer. 2013.PMID:23292955Free PMC article.
- Novel bispecific antibody-drug conjugate targeting PD-L1 and B7-H3 enhances antitumor efficacy and promotes immune-mediated antitumor responses.Dong Y, Zhang Z, Luan S, Zheng M, Wang Z, Chen Y, Chen X, Tong A, Yang H.Dong Y, et al.J Immunother Cancer. 2024 Oct 2;12(10):e009710. doi: 10.1136/jitc-2024-009710.J Immunother Cancer. 2024.PMID:39357981Free PMC article.
- Arginylated calreticulin at plasma membrane increases susceptibility of cells to apoptosis.López Sambrooks C, Carpio MA, Hallak ME.López Sambrooks C, et al.J Biol Chem. 2012 Jun 22;287(26):22043-54. doi: 10.1074/jbc.M111.338335. Epub 2012 May 10.J Biol Chem. 2012.PMID:22577148Free PMC article.
- Cancer Immune Therapy for Philadelphia Chromosome-Negative Chronic Myeloproliferative Neoplasms.Holmström MO, Hasselbalch HC, Andersen MH.Holmström MO, et al.Cancers (Basel). 2020 Jul 2;12(7):1763. doi: 10.3390/cancers12071763.Cancers (Basel). 2020.PMID:32630667Free PMC article.Review.
- Extracorporeal Photopheresis: Tolerogenic or Immunogenic Cell Death? Beyond Current Dogma.Hannani D.Hannani D.Front Immunol. 2015 Jul 7;6:349. doi: 10.3389/fimmu.2015.00349. eCollection 2015.Front Immunol. 2015.PMID:26217341Free PMC article.Review.No abstract available.
Publication types
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials