doi: 10.1084/jem.20051600.
Functionally distinct NKT cell subsets and subtypes
Affiliations
- PMID:16365145
- PMCID: PMC2212962
- DOI: 10.1084/jem.20051600
Item in Clipboard
Functionally distinct NKT cell subsets and subtypes
Ken-Ichiro Seino et al. J Exp Med..
Display options
Format
Display options
Format
Abstract
Natural killer T (NKT) cells are a population of autoreactive cells that mediate both protective and regulatory immune functions. NKT cells comprise several subsets of cells, but it has been unclear whether these different NKT cell subsets possess distinct functions in vivo. New studies now demonstrate that subsets of NKT cells are indeed functionally distinct and that the specific functions of these cells may be dictated in part by organ-specific mechanisms.
Figures
Potential mechanisms by which tissue-specific NKT cell subsets acquire distinct functions. NKT cells from different organs have been reported to have distinct functions. For example, double negative (DN) NKT cells in the liver mediate tumor rejection (reference 6), and DN NKT cells from the thymus regulate immune cell function in the NOD mouse model of type I diabetes (reference 8). These functionally distinct populations of NKT cells might arise from the same NKT cell precursors in the thymus. However, unidentified organ-specific factors might dictate the function of local NKT cell populations. Local dendritic cell populations (either stimulatory or regulatory) that interact with NKT cells might also influence local NKT cell function.
Similar articles
- Assessment of natural killer (NK) and NKT cells in murine spleens and livers.Shey MR, Ballas ZK.Shey MR, et al.Methods Mol Biol. 2008;447:259-76. doi: 10.1007/978-1-59745-242-7_18.Methods Mol Biol. 2008.PMID:18369924
- Activation of natural killer T cells by glycolipids.Tupin E, Kronenberg M.Tupin E, et al.Methods Enzymol. 2006;417:185-201. doi: 10.1016/S0076-6879(06)17014-7.Methods Enzymol. 2006.PMID:17132506Review.
- Molecular profiling reveals distinct functional attributes of CD1d-restricted natural killer (NK) T cell subsets.Rolf J, Berntman E, Stenström M, Smith EM, Månsson R, Stenstad H, Yamagata T, Agace W, Sigvardsson M, Cardell SL.Rolf J, et al.Mol Immunol. 2008 May;45(9):2607-20. doi: 10.1016/j.molimm.2007.12.022. Epub 2008 Mar 4.Mol Immunol. 2008.PMID:18304639
- Analysis of the effect of different NKT cell subpopulations on the activation of CD4 and CD8 T cells, NK cells, and B cells.Lin H, Nieda M, Rozenkov V, Nicol AJ.Lin H, et al.Exp Hematol. 2006 Mar;34(3):289-95. doi: 10.1016/j.exphem.2005.12.008.Exp Hematol. 2006.PMID:16543063
- Regulation of type 1 diabetes by NKT cells.Novak J, Griseri T, Beaudoin L, Lehuen A.Novak J, et al.Int Rev Immunol. 2007 Jan-Apr;26(1-2):49-72. doi: 10.1080/08830180601070229.Int Rev Immunol. 2007.PMID:17454264Review.
Cited by
- Non-classical natural killer T cells modulate plasmid DNA vaccine antigen expression and vaccine-elicited immune responses by MCP-1 secretion after interaction with a beta2-microglobulin-independent CD1d.Geiben-Lynn R, Greenland JR, Frimpong-Boateng K, Letvin NL.Geiben-Lynn R, et al.J Biol Chem. 2009 Dec 4;284(49):33800-6. doi: 10.1074/jbc.M109.019638. Epub 2009 Oct 15.J Biol Chem. 2009.PMID:19833737Free PMC article.
- Chronic inflammation and asthma.Murdoch JR, Lloyd CM.Murdoch JR, et al.Mutat Res. 2010 Aug 7;690(1-2):24-39. doi: 10.1016/j.mrfmmm.2009.09.005. Epub 2009 Sep 19.Mutat Res. 2010.PMID:19769993Free PMC article.Review.
- NKT cells are necessary for maximal expression of allergic conjunctivitis.Reyes NJ, Mayhew E, Chen PW, Niederkorn JY.Reyes NJ, et al.Int Immunol. 2010 Aug;22(8):627-36. doi: 10.1093/intimm/dxq046. Epub 2010 May 26.Int Immunol. 2010.PMID:20504886Free PMC article.
- Combination of intratumoral invariant natural killer T cells and interferon-gamma is associated with prognosis of hepatocellular carcinoma after curative resection.Xiao YS, Gao Q, Xu XN, Li YW, Ju MJ, Cai MY, Dai CX, Hu J, Qiu SJ, Zhou J, Fan J.Xiao YS, et al.PLoS One. 2013 Aug 5;8(8):e70345. doi: 10.1371/journal.pone.0070345. Print 2013.PLoS One. 2013.PMID:23940564Free PMC article.
- Unbiased Screening Identifies Functional Differences in NK Cells After Early Life Psychosocial Stress.Fernandes SB, Patil ND, Meriaux S, Theresine M, Muller CP, Leenen FAD, Elwenspoek MMC, Zimmer J, Turner JD.Fernandes SB, et al.Front Immunol. 2021 Jul 30;12:674532. doi: 10.3389/fimmu.2021.674532. eCollection 2021.Front Immunol. 2021.PMID:34394074Free PMC article.
References
- Woodland, D.L., and R.W. Dutton. 2003. Heterogeneity of CD4+ and CD8+ T cells. Curr. Opin. Immunol. 15:336–342. - PubMed
- Zhou, D., J. Mattner, C. Cantu III, N. Schrantz, N. Yin, Y. Gao, Y. Sagiv, K. Hudspeth, Y.P. Wu, T. Yamashita, et al. 2004. Lysosomal glycosphingolipid recognition by NKT cells. Science. 306:1786–1789. - PubMed
- Taniguchi, M., M. Harada, S. Kojo, T. Nakayama, and H. Wakao. 2003. The regulatory role of Vα14NKT cells in innate and acquired immune response. Annu. Rev. Immunol. 21:483–513. - PubMed
- Godfrey, D.I., H.R. Macdonald, M. Kronenberg, M.J. Smyth, and L. Van Kaer. 2004. NKT cells: what's in a name? Nat. Rev. Immunol. 4:231–237. - PubMed